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- W2159380558 abstract "Recombinant human interleukin-10 (hIL-10) is highly expressed in transgenic rice endosperm and forms active homodimers in the ER-derived hIL-10 body. In this study, we examined the preclinical efficacy of transgenic rice accumulating hIL-10 (hIL-10 rice) in in vivo experimental mouse models of colitis and pollen allergy. In the group of mice orally fed hIL-10 rice, the development of Japanese cedar pollen allergen-specific IgE and splenic T cell responses were significantly inhibited. In addition, oral feeding of hIL-10 rice showed therapeutic as well as prophylactic efficacy against experimental colitis developed in IL-10-deficient mice. These results indicate the clinical potentiality of hIL-10 rice for the control of inflammatory and allergic disorders through efficient delivery of hIL-10 to the gut-associated lymphoid tissue." @default.
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- W2159380558 date "2015-01-01" @default.
- W2159380558 modified "2023-10-01" @default.
- W2159380558 title "Efficacy of transgenic rice containing human interleukin-10 in experimental mouse models of colitis and pollen allergy" @default.
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- W2159380558 doi "https://doi.org/10.5511/plantbiotechnology.15.0808a" @default.
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