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• W2159389701 endingPage "443" @default.
• W2159389701 startingPage "434" @default.
• W2159389701 abstract "ABSTRACT T-cell immunity is critical for survival of hosts infected with Toxoplasma gondii. Among the cells in the T-cell population, CD8 + T cells are considered the major effector cells against this parasite. It is believed that CD4 + T cells may be crucial for induction of the CD8 + -T-cell response against T. gondii . In the present study, CD4 −/− mice were used to evaluate the role of conventional CD4 + T cells in the immune response against T. gondii infection. CD4 −/− mice infected with T. gondii exhibited lower gamma interferon (IFN-γ) messages in the majority of their tissues. As a result, mortality due to a hyperinflammatory response was prevented in these animals. Interestingly, T. gondii infection induced a normal antigen-specific CD8 + -T-cell immune response in CD4 −/− mice. No difference in generation of precursor cytotoxic T lymphocytes (pCTL) or in IFN-γ production by the CD8 + -T-cell populations from the knockout and wild-type animals was observed. However, the mutant mice were not able to sustain CD8 + -T-cell immunity. At 180 days after infection, the CD8 + -T-cell response in the knockout mice was depressed, as determined by pCTL and IFN-γ assays. Loss of CD8 + -T-cell immunity at this time was confirmed by adoptive transfer experiments. Purified CD8 + T cells from CD4 −/− donors that had been immunized 180 days earlier failed to protect the recipient mice against a lethal infection. Our study demonstrated that although CD8 + -T-cell immunity can be induced in the absence of conventional CD4 + T cells, it cannot be maintained without such cells." @default.
• W2159389701 created "2016-06-24" @default.
• W2159389701 creator A5013521387 @default.
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• W2159389701 date "2002-02-01" @default.
• W2159389701 modified "2023-10-01" @default.
• W2159389701 title "CD8⁺-T-Cell Immunity against<i>Toxoplasma gondii</i>Can Be Induced but Not Maintained in Mice Lacking Conventional CD4⁺T Cells" @default.
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• W2159389701 doi "https://doi.org/10.1128/iai.70.2.434-443.2002" @default.
• W2159389701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/127655" @default.
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