FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159400527> ?p ?o ?g. }

• W2159400527 endingPage "3743" @default.
• W2159400527 startingPage "3730" @default.
• W2159400527 abstract "Plant metabolites are valuable sources of novel therapeutic compounds. In an anti-telomerase screening study of plant secondary metabolites, the aporphine alkaloid boldine (1,10-dimethoxy-2,9-dihydroxyaporphine) exhibited a dose and time dependent cytotoxicity against hepatocarcinoma HepG-2 cells. Here we focus on the modes and mechanisms of the growth-limiting effects of this compound. Telomerase activity and expression level of some related genes were estimated by real-time PCR. Modes of cell death also were examined by microscopic inspection, staining methods and by evaluating the expression level of some critically relevant genes. The growth inhibition was correlated with down-regulation of the catalytic subunit of telomerase (hTERT) gene (p < 0.01) and the corresponding reduction of telomerase activity in sub-cytotoxic concentrations of boldine (p < 0.002). However, various modes of cell death were stimulated, depending on the concentration of boldine. Very low concentrations of boldine over a few passages resulted in an accumulation of senescent cells so that HepG-2 cells lost their immortality. Moreover, boldine induced apoptosis concomitantly with increasing the expression of bax/bcl2 (p < 0.02) and p21 (p < 0.01) genes. Boldine might thus be an interesting candidate as a potential natural compound that suppresses telomerase activity in non-toxic concentrations." @default.
• W2159400527 created "2016-06-24" @default.
• W2159400527 creator A5034011528 @default.
• W2159400527 creator A5066578159 @default.
• W2159400527 date "2015-02-24" @default.
• W2159400527 modified "2023-10-12" @default.
• W2159400527 title "Dose-Dependent Cytotoxic Effects of Boldine in HepG-2 Cells—Telomerase Inhibition and Apoptosis Induction" @default.
• W2159400527 cites W1539469412 @default.
• W2159400527 cites W1545076822 @default.
• W2159400527 cites W1607660496 @default.
• W2159400527 cites W1969556388 @default.
• W2159400527 cites W1971459120 @default.
• W2159400527 cites W1973988625 @default.
• W2159400527 cites W1975831195 @default.
• W2159400527 cites W1980483408 @default.
• W2159400527 cites W1985628991 @default.
• W2159400527 cites W1998663807 @default.
• W2159400527 cites W2002435695 @default.
• W2159400527 cites W2013427923 @default.
• W2159400527 cites W2023859567 @default.
• W2159400527 cites W2029296770 @default.
• W2159400527 cites W2030231219 @default.
• W2159400527 cites W2030976397 @default.
• W2159400527 cites W2034577150 @default.
• W2159400527 cites W2044507716 @default.
• W2159400527 cites W2044606083 @default.
• W2159400527 cites W2051090838 @default.
• W2159400527 cites W2055224253 @default.
• W2159400527 cites W2056878496 @default.
• W2159400527 cites W2057132218 @default.
• W2159400527 cites W2059847417 @default.
• W2159400527 cites W2061245959 @default.
• W2159400527 cites W2075404899 @default.
• W2159400527 cites W2077183901 @default.
• W2159400527 cites W2087565842 @default.
• W2159400527 cites W2093180770 @default.
• W2159400527 cites W2093910256 @default.
• W2159400527 cites W2096394765 @default.
• W2159400527 cites W2100215079 @default.
• W2159400527 cites W2100550233 @default.
• W2159400527 cites W2104908670 @default.
• W2159400527 cites W2106876162 @default.
• W2159400527 cites W2114918609 @default.
• W2159400527 cites W2118388996 @default.
• W2159400527 cites W2120086108 @default.
• W2159400527 cites W2121097260 @default.
• W2159400527 cites W2121297790 @default.
• W2159400527 cites W2126850174 @default.
• W2159400527 cites W2132882668 @default.
• W2159400527 cites W2153117006 @default.
• W2159400527 cites W2162262059 @default.
• W2159400527 cites W2163949700 @default.
• W2159400527 cites W2165220969 @default.
• W2159400527 cites W2319007677 @default.
• W2159400527 cites W2410460617 @default.
• W2159400527 cites W3120784158 @default.
• W2159400527 doi "https://doi.org/10.3390/molecules20033730" @default.
• W2159400527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6272231" @default.
• W2159400527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25719742" @default.
• W2159400527 hasPublicationYear "2015" @default.
• W2159400527 type Work @default.
• W2159400527 sameAs 2159400527 @default.
• W2159400527 citedByCount "22" @default.
• W2159400527 countsByYear W21594005272015 @default.
• W2159400527 countsByYear W21594005272016 @default.
• W2159400527 countsByYear W21594005272017 @default.
• W2159400527 countsByYear W21594005272018 @default.
• W2159400527 countsByYear W21594005272019 @default.
• W2159400527 countsByYear W21594005272020 @default.
• W2159400527 countsByYear W21594005272021 @default.
• W2159400527 countsByYear W21594005272022 @default.
• W2159400527 countsByYear W21594005272023 @default.
• W2159400527 crossrefType "journal-article" @default.
• W2159400527 hasAuthorship W2159400527A5034011528 @default.
• W2159400527 hasAuthorship W2159400527A5066578159 @default.
• W2159400527 hasBestOaLocation W21594005271 @default.
• W2159400527 hasConcept C104292427 @default.
• W2159400527 hasConcept C104317684 @default.
• W2159400527 hasConcept C109316439 @default.
• W2159400527 hasConcept C125593758 @default.
• W2159400527 hasConcept C153911025 @default.
• W2159400527 hasConcept C154317977 @default.
• W2159400527 hasConcept C185592680 @default.
• W2159400527 hasConcept C190283241 @default.
• W2159400527 hasConcept C202751555 @default.
• W2159400527 hasConcept C2777667214 @default.
• W2159400527 hasConcept C2778079118 @default.
• W2159400527 hasConcept C2779707156 @default.
• W2159400527 hasConcept C31573885 @default.
• W2159400527 hasConcept C55493867 @default.
• W2159400527 hasConcept C71240020 @default.
• W2159400527 hasConcept C86803240 @default.
• W2159400527 hasConcept C94581717 @default.
• W2159400527 hasConcept C95444343 @default.
• W2159400527 hasConceptScore W2159400527C104292427 @default.
• W2159400527 hasConceptScore W2159400527C104317684 @default.
• W2159400527 hasConceptScore W2159400527C109316439 @default.
• W2159400527 hasConceptScore W2159400527C125593758 @default.

• next