Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159409429> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2159409429 abstract "Aim and objectives: β-thalassemia arises from a defect in the β globuli n chain synthesis from clinically silent heterogeneous thalassemia minor to severe transfusion dependent thalassemia major. Transfusion related iron overload is the primary therapeutic complication in β-thalassemia major which leads to peroxidative stress and adversely affects the functioning of multiple organs. Hypothalamic–pituitary –thyroid axis, para-thyroid, adrenal, pancreas, gonads, all may show hypo-activ ity. The prognosis depends on the amount and the duration of iron overload. Therefore the aim of this study was to evaluate the thyroid hormones in patients with β TM in a children’s hospital in New Delhi, India. Materials and Methods: 68 patients (aged 1-12 years) with β -thalassemia major that undergo periodical blood transfusion at Chacha Nehru Bal Chikitsalya Hospital, New Delhi were included in the study. The diagnosis was based on clinical examination and haematological and haemoglobin electrophoresis profile. Serum levels of ferritin, iron, thyroid hormones FT3, FT4 and TSH levels along with bilirubin and transaminases were estimated in all children. Results: Subclinical hypothyroidism was observed in 23 patients (34%), who were further divided into 2 groups: - compensated hypothyroidism which included 16 patients (24%) and decompensated hypothyroidism with 7 patients (10%). 45 patients (66%) were found to be euthyroid. No significant worsening of thyroid profile was observed after one year of study. Conclusion: Hypothyroidism is a frequent complication of excess iron load in thalassemia major patients. It is not clinically observed in most thalassemia major patients and regular monitoring for the early detection and timely treatment of the disorder should be implemented in all thalassemic children." @default.
- W2159409429 created "2016-06-24" @default.
- W2159409429 creator A5010932929 @default.
- W2159409429 creator A5016419834 @default.
- W2159409429 creator A5038243047 @default.
- W2159409429 creator A5069034128 @default.
- W2159409429 creator A5073958293 @default.
- W2159409429 date "2014-03-01" @default.
- W2159409429 modified "2023-09-23" @default.
- W2159409429 title "EVALUATION OF THYROID HORMONES IN B THALASSEMIC CHILDREN OF NORTH INDIA" @default.
- W2159409429 cites W126722290 @default.
- W2159409429 cites W1491532645 @default.
- W2159409429 cites W16239601 @default.
- W2159409429 cites W1964474926 @default.
- W2159409429 cites W2059107234 @default.
- W2159409429 cites W2068337287 @default.
- W2159409429 cites W2076575287 @default.
- W2159409429 cites W2107407875 @default.
- W2159409429 cites W2120758272 @default.
- W2159409429 cites W2123152382 @default.
- W2159409429 cites W2131291367 @default.
- W2159409429 cites W2142924037 @default.
- W2159409429 cites W2189173411 @default.
- W2159409429 cites W2769412925 @default.
- W2159409429 cites W2742055660 @default.
- W2159409429 hasPublicationYear "2014" @default.
- W2159409429 type Work @default.
- W2159409429 sameAs 2159409429 @default.
- W2159409429 citedByCount "1" @default.
- W2159409429 countsByYear W21594094292014 @default.
- W2159409429 crossrefType "journal-article" @default.
- W2159409429 hasAuthorship W2159409429A5010932929 @default.
- W2159409429 hasAuthorship W2159409429A5016419834 @default.
- W2159409429 hasAuthorship W2159409429A5038243047 @default.
- W2159409429 hasAuthorship W2159409429A5069034128 @default.
- W2159409429 hasAuthorship W2159409429A5073958293 @default.
- W2159409429 hasConcept C113280763 @default.
- W2159409429 hasConcept C126322002 @default.
- W2159409429 hasConcept C134018914 @default.
- W2159409429 hasConcept C187212893 @default.
- W2159409429 hasConcept C2777195454 @default.
- W2159409429 hasConcept C2777799968 @default.
- W2159409429 hasConcept C2780014101 @default.
- W2159409429 hasConcept C526584372 @default.
- W2159409429 hasConcept C71315377 @default.
- W2159409429 hasConcept C71924100 @default.
- W2159409429 hasConcept C81182388 @default.
- W2159409429 hasConcept C90924648 @default.
- W2159409429 hasConceptScore W2159409429C113280763 @default.
- W2159409429 hasConceptScore W2159409429C126322002 @default.
- W2159409429 hasConceptScore W2159409429C134018914 @default.
- W2159409429 hasConceptScore W2159409429C187212893 @default.
- W2159409429 hasConceptScore W2159409429C2777195454 @default.
- W2159409429 hasConceptScore W2159409429C2777799968 @default.
- W2159409429 hasConceptScore W2159409429C2780014101 @default.
- W2159409429 hasConceptScore W2159409429C526584372 @default.
- W2159409429 hasConceptScore W2159409429C71315377 @default.
- W2159409429 hasConceptScore W2159409429C71924100 @default.
- W2159409429 hasConceptScore W2159409429C81182388 @default.
- W2159409429 hasConceptScore W2159409429C90924648 @default.
- W2159409429 hasIssue "01" @default.
- W2159409429 hasLocation W21594094291 @default.
- W2159409429 hasOpenAccess W2159409429 @default.
- W2159409429 hasPrimaryLocation W21594094291 @default.
- W2159409429 hasRelatedWork W1515748290 @default.
- W2159409429 hasRelatedWork W189886111 @default.
- W2159409429 hasRelatedWork W1995034127 @default.
- W2159409429 hasRelatedWork W2067014948 @default.
- W2159409429 hasRelatedWork W2107407875 @default.
- W2159409429 hasRelatedWork W2273987341 @default.
- W2159409429 hasRelatedWork W2317940171 @default.
- W2159409429 hasRelatedWork W2468492780 @default.
- W2159409429 hasRelatedWork W2611578692 @default.
- W2159409429 hasRelatedWork W2801512898 @default.
- W2159409429 hasRelatedWork W2891925960 @default.
- W2159409429 hasRelatedWork W2896761318 @default.
- W2159409429 hasRelatedWork W2940334758 @default.
- W2159409429 hasRelatedWork W2988592912 @default.
- W2159409429 hasRelatedWork W2996705651 @default.
- W2159409429 hasRelatedWork W3043063824 @default.
- W2159409429 hasRelatedWork W3118924325 @default.
- W2159409429 hasRelatedWork W3143883297 @default.
- W2159409429 hasRelatedWork W3169691167 @default.
- W2159409429 hasRelatedWork W2186773453 @default.
- W2159409429 hasVolume "02" @default.
- W2159409429 isParatext "false" @default.
- W2159409429 isRetracted "false" @default.
- W2159409429 magId "2159409429" @default.
- W2159409429 workType "article" @default.