FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159448723> ?p ?o ?g. }

• W2159448723 abstract "The striking female predominance in idiopathic and familial pulmonary arterial hypertension (PAH) has been well documented since the publication of the National Institutes of Health (NIH) registry in 1987 [1]. In the majority of PAH registries, females are at least twice as likely to be represented as males, with female to male ratios as high as four to one [2–6]. Notably, these sex differences are not fully explained by a differential distribution of known risk factors for PAH by sex, such as autoimmune disease or anorexigen exposure. Taken together, these epidemiological data suggest that other sex-associated factors, including sex hormones, may influence PAH pathogenesis.Endogenous and exogenous sex hormone exposures represent a biologically plausible potential risk factor for PAH. Sex hormones determine in utero organ development, drive tissue-specific changes in early life and exert an evolving influence across the life span as their absolute and relative concentrations shift [7]. There can be no doubt that sex hormones, with their ability to modulate vascular tone, inflammation and remodelling, play a fundamental role in determining cardiovascular phenotypes [8]. Emerging data on the importance of sex hormones in animal models of pulmonary hypertension provide tantalising evidence that the pulmonary vascular phenotype of an organism is dependent upon these pleiotropic signalling molecules [9, 10].In this issue of the European Respiratory Journal , Yuan et al. [11] demonstrate that monocrotaline (MCT) creates an oestrogen-deficient state in rats characterised by low plasma oestradiol (E2) and altered pulmonary expression of oestrogen receptors and enzymes responsible for E2 anabolism (reduced) and catabolism (increased). In the absence of sufficient endogenous ( i.e. post-ovariectomy) or exogenous oestradiol, a pro-proliferative, anti-apoptotic and vasoconstrictive phenotype emerges that is mediated in part via reduced nitric oxide and prostacyclin, and increased endothelin. Rescue of the …" @default.
• W2159448723 created "2016-06-24" @default.
• W2159448723 creator A5012476885 @default.
• W2159448723 creator A5014632945 @default.
• W2159448723 date "2013-04-30" @default.
• W2159448723 modified "2023-09-25" @default.
• W2159448723 title "Oestrogen and the sexual dimorphism of pulmonary arterial hypertension: a translational challenge" @default.
• W2159448723 cites W1977966424 @default.
• W2159448723 cites W1981493632 @default.
• W2159448723 cites W1984693219 @default.
• W2159448723 cites W1987540231 @default.
• W2159448723 cites W2011071006 @default.
• W2159448723 cites W2021595474 @default.
• W2159448723 cites W2032088699 @default.
• W2159448723 cites W2046393134 @default.
• W2159448723 cites W2053765786 @default.
• W2159448723 cites W2055638366 @default.
• W2159448723 cites W2065938972 @default.
• W2159448723 cites W2090144219 @default.
• W2159448723 cites W2095194453 @default.
• W2159448723 cites W2100471651 @default.
• W2159448723 cites W2104369067 @default.
• W2159448723 cites W2106199142 @default.
• W2159448723 cites W2106815412 @default.
• W2159448723 cites W2107785527 @default.
• W2159448723 cites W2111967052 @default.
• W2159448723 cites W2114863766 @default.
• W2159448723 cites W2123330610 @default.
• W2159448723 cites W2133403604 @default.
• W2159448723 cites W2134612237 @default.
• W2159448723 cites W2140148084 @default.
• W2159448723 cites W2141262339 @default.
• W2159448723 cites W2141987653 @default.
• W2159448723 cites W2147841879 @default.
• W2159448723 cites W2154332638 @default.
• W2159448723 cites W2158891637 @default.
• W2159448723 cites W2160856149 @default.
• W2159448723 cites W2161520297 @default.
• W2159448723 cites W2165248837 @default.
• W2159448723 cites W2168595762 @default.
• W2159448723 cites W2169001316 @default.
• W2159448723 cites W2201893451 @default.
• W2159448723 cites W2615633554 @default.
• W2159448723 cites W2988610037 @default.
• W2159448723 doi "https://doi.org/10.1183/09031936.00021713" @default.
• W2159448723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23633611" @default.
• W2159448723 hasPublicationYear "2013" @default.
• W2159448723 type Work @default.
• W2159448723 sameAs 2159448723 @default.
• W2159448723 citedByCount "3" @default.
• W2159448723 countsByYear W21594487232013 @default.
• W2159448723 countsByYear W21594487232018 @default.
• W2159448723 crossrefType "journal-article" @default.
• W2159448723 hasAuthorship W2159448723A5012476885 @default.
• W2159448723 hasAuthorship W2159448723A5014632945 @default.
• W2159448723 hasBestOaLocation W21594487231 @default.
• W2159448723 hasConcept C104317684 @default.
• W2159448723 hasConcept C105083479 @default.
• W2159448723 hasConcept C126322002 @default.
• W2159448723 hasConcept C127716648 @default.
• W2159448723 hasConcept C134018914 @default.
• W2159448723 hasConcept C172268261 @default.
• W2159448723 hasConcept C2777164284 @default.
• W2159448723 hasConcept C2777911890 @default.
• W2159448723 hasConcept C2778945730 @default.
• W2159448723 hasConcept C2780930700 @default.
• W2159448723 hasConcept C2780942790 @default.
• W2159448723 hasConcept C30092816 @default.
• W2159448723 hasConcept C42407357 @default.
• W2159448723 hasConcept C55493867 @default.
• W2159448723 hasConcept C71315377 @default.
• W2159448723 hasConcept C71924100 @default.
• W2159448723 hasConcept C86803240 @default.
• W2159448723 hasConceptScore W2159448723C104317684 @default.
• W2159448723 hasConceptScore W2159448723C105083479 @default.
• W2159448723 hasConceptScore W2159448723C126322002 @default.
• W2159448723 hasConceptScore W2159448723C127716648 @default.
• W2159448723 hasConceptScore W2159448723C134018914 @default.
• W2159448723 hasConceptScore W2159448723C172268261 @default.
• W2159448723 hasConceptScore W2159448723C2777164284 @default.
• W2159448723 hasConceptScore W2159448723C2777911890 @default.
• W2159448723 hasConceptScore W2159448723C2778945730 @default.
• W2159448723 hasConceptScore W2159448723C2780930700 @default.
• W2159448723 hasConceptScore W2159448723C2780942790 @default.
• W2159448723 hasConceptScore W2159448723C30092816 @default.
• W2159448723 hasConceptScore W2159448723C42407357 @default.
• W2159448723 hasConceptScore W2159448723C55493867 @default.
• W2159448723 hasConceptScore W2159448723C71315377 @default.
• W2159448723 hasConceptScore W2159448723C71924100 @default.
• W2159448723 hasConceptScore W2159448723C86803240 @default.
• W2159448723 hasLocation W21594487231 @default.
• W2159448723 hasLocation W21594487232 @default.
• W2159448723 hasOpenAccess W2159448723 @default.
• W2159448723 hasPrimaryLocation W21594487231 @default.
• W2159448723 hasRelatedWork W1608365260 @default.
• W2159448723 hasRelatedWork W1983568194 @default.
• W2159448723 hasRelatedWork W1999344102 @default.
• W2159448723 hasRelatedWork W2012851990 @default.
• W2159448723 hasRelatedWork W2037662832 @default.
• W2159448723 hasRelatedWork W2039868006 @default.

• next