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- W2159454920 abstract "Differences greater than 6,000-fold in the mutagenic potency of three nitro-samides that are methylating agents [N-methyl-N-nitrosourea (MNU), N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and N-nitrosocarbaryl (NC)] could be accounted for in part by differences in their uptake into the Haemophilus influenzae cells. Uptake was roughly correlated with the octanol/water partition coefficient. The most potent mutagen, NC, was concentrated by the cells. The least potent, MNU, was essentially excluded from the bacteria. Uptake was a linear function of concentration, whereas induction of novobiocin-resistant mutations followed higher-order kinetics. The effective dose of chemical to the bacteria (number of molecules taken up) under conditions of mutagenesis could be calculated." @default.
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- W2159454920 date "1979-01-01" @default.
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- W2159454920 title "Mutagenicity of nitrosocarbaryl and other methylating nitrosamides as related to uptake in haemophilus influenzae" @default.
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- W2159454920 doi "https://doi.org/10.1002/em.2860010307" @default.
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