FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159458476> ?p ?o ?g. }

• W2159458476 endingPage "295" @default.
• W2159458476 startingPage "285" @default.
• W2159458476 abstract "Purpose : Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small number of samples as well as the present pilot study also suggested that BRCA1 heterozygosity may lead to impaired repair of ionizing-radiation-induced DNA double-strand breaks. The purpose of the study was to test in a larger family-matched study whether carriers of BRCA1 or BRCA2 mutations have an increased sensitivity to ionizing radiation. Materials and methods : In a blind study, the effect of different germ-line mutations in one allele of the BRCA1 or BRCA2 gene on the ability to repair X-ray-induced DNA breaks was investigated. Fibroblasts and lymphocytes were taken from heterozygotic individuals (BRCA1+ /- and BRCA2+ /-) with different mutations and from relatives proven to be non-carriers of the BRCA mutations. Rejoining of DNA breaks was analysed by pulsed-field gel electrophoresis (for fibroblasts) or the comet assay (for lymphocytes). Results : Significant interindividual differences were found in the capacities of the fibroblasts and lymphocytes to rejoin DNA breaks induced by X-radiation. However, these differences were not related to heterozygosity in BRCA1 or BRCA2. Conclusions : Cells from carriers of mutations in one allele of the BRCA1 or BRCA2 genes have no gross defects in their ability to rejoin radiation-induced DNA breaks. Hence, these carriers may not be at risk of developing excess normal tissue reactions after radiotherapy consistent with data from recent clinical studies." @default.
• W2159458476 created "2016-06-24" @default.
• W2159458476 creator A5035802047 @default.
• W2159458476 creator A5036474885 @default.
• W2159458476 creator A5042480102 @default.
• W2159458476 creator A5056016738 @default.
• W2159458476 creator A5059518645 @default.
• W2159458476 creator A5066688208 @default.
• W2159458476 creator A5076711531 @default.
• W2159458476 creator A5081115482 @default.
• W2159458476 date "2002-01-01" @default.
• W2159458476 modified "2023-09-27" @default.
• W2159458476 title "BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage" @default.
• W2159458476 cites W1515564094 @default.
• W2159458476 cites W1516092031 @default.
• W2159458476 cites W1755597336 @default.
• W2159458476 cites W1828494712 @default.
• W2159458476 cites W1879187490 @default.
• W2159458476 cites W1965159396 @default.
• W2159458476 cites W1965421709 @default.
• W2159458476 cites W1977035912 @default.
• W2159458476 cites W1989802855 @default.
• W2159458476 cites W1992121629 @default.
• W2159458476 cites W1999002383 @default.
• W2159458476 cites W2001461026 @default.
• W2159458476 cites W2002555966 @default.
• W2159458476 cites W2012300945 @default.
• W2159458476 cites W2019205168 @default.
• W2159458476 cites W2022176772 @default.
• W2159458476 cites W2022253294 @default.
• W2159458476 cites W2024963375 @default.
• W2159458476 cites W2028376261 @default.
• W2159458476 cites W2032298890 @default.
• W2159458476 cites W2035724529 @default.
• W2159458476 cites W2037191150 @default.
• W2159458476 cites W2049598883 @default.
• W2159458476 cites W2053950888 @default.
• W2159458476 cites W2057949133 @default.
• W2159458476 cites W2058664192 @default.
• W2159458476 cites W2061151099 @default.
• W2159458476 cites W2066108933 @default.
• W2159458476 cites W2071850617 @default.
• W2159458476 cites W2084181149 @default.
• W2159458476 cites W2088179903 @default.
• W2159458476 cites W2091350790 @default.
• W2159458476 cites W2107943906 @default.
• W2159458476 cites W2121649591 @default.
• W2159458476 cites W2122089700 @default.
• W2159458476 cites W2123166592 @default.
• W2159458476 cites W2166804883 @default.
• W2159458476 cites W2330837897 @default.
• W2159458476 doi "https://doi.org/10.1080/09553000110097974" @default.
• W2159458476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12020440" @default.
• W2159458476 hasPublicationYear "2002" @default.
• W2159458476 type Work @default.
• W2159458476 sameAs 2159458476 @default.
• W2159458476 citedByCount "55" @default.
• W2159458476 countsByYear W21594584762012 @default.
• W2159458476 countsByYear W21594584762013 @default.
• W2159458476 countsByYear W21594584762014 @default.
• W2159458476 countsByYear W21594584762015 @default.
• W2159458476 countsByYear W21594584762016 @default.
• W2159458476 countsByYear W21594584762017 @default.
• W2159458476 countsByYear W21594584762019 @default.
• W2159458476 countsByYear W21594584762020 @default.
• W2159458476 countsByYear W21594584762021 @default.
• W2159458476 crossrefType "journal-article" @default.
• W2159458476 hasAuthorship W2159458476A5035802047 @default.
• W2159458476 hasAuthorship W2159458476A5036474885 @default.
• W2159458476 hasAuthorship W2159458476A5042480102 @default.
• W2159458476 hasAuthorship W2159458476A5056016738 @default.
• W2159458476 hasAuthorship W2159458476A5059518645 @default.
• W2159458476 hasAuthorship W2159458476A5066688208 @default.
• W2159458476 hasAuthorship W2159458476A5076711531 @default.
• W2159458476 hasAuthorship W2159458476A5081115482 @default.
• W2159458476 hasConcept C104317684 @default.
• W2159458476 hasConcept C104451858 @default.
• W2159458476 hasConcept C111337013 @default.
• W2159458476 hasConcept C121332964 @default.
• W2159458476 hasConcept C134935766 @default.
• W2159458476 hasConcept C143425029 @default.
• W2159458476 hasConcept C143589142 @default.
• W2159458476 hasConcept C145803527 @default.
• W2159458476 hasConcept C153911025 @default.
• W2159458476 hasConcept C180754005 @default.
• W2159458476 hasConcept C18231593 @default.
• W2159458476 hasConcept C185544564 @default.
• W2159458476 hasConcept C2780358455 @default.
• W2159458476 hasConcept C501734568 @default.
• W2159458476 hasConcept C502942594 @default.
• W2159458476 hasConcept C54355233 @default.
• W2159458476 hasConcept C552990157 @default.
• W2159458476 hasConcept C86803240 @default.
• W2159458476 hasConceptScore W2159458476C104317684 @default.
• W2159458476 hasConceptScore W2159458476C104451858 @default.
• W2159458476 hasConceptScore W2159458476C111337013 @default.
• W2159458476 hasConceptScore W2159458476C121332964 @default.
• W2159458476 hasConceptScore W2159458476C134935766 @default.

• next