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- W2159470585 abstract "ABSTRACT The contribution of amebiasis to the burden of diarrheal disease in children and the degree to which immunity is acquired from natural infection were assessed in a 4-year prospective observational study of 289 preschool children in an urban slum in Dhaka, Bangladesh. Entamoeba histolytica infection was detected at least once in 80%, and repeat infection in 53%, of the children who completed 4 years of observation. Annually there were 0.09 episodes/child of E. histolytica- associated diarrhea and 0.03 episodes/child of E. histolytica- associated dysentery. Fecal immunoglobulin A (IgA) anti-parasite Gal/GalNAc lectin carbohydrate recognition domain (anti-CRD) was detected in 91% (183/202) of the children at least once and was associated with a lower incidence of infection and disease. We concluded that amebiasis was a substantial burden on the overall health of the cohort children. Protection from amebiasis was associated with a stool anti-CRD IgA response. The challenge of producing an effective vaccine will be to improve upon naturally acquired immunity, which does not provide absolute protection from reinfection." @default.
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- W2159470585 date "2006-02-01" @default.
- W2159470585 modified "2023-10-14" @default.
- W2159470585 title "<i>Entamoeba histolytica</i> Infection in Children and Protection from Subsequent Amebiasis" @default.
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- W2159470585 doi "https://doi.org/10.1128/iai.74.2.904-909.2006" @default.
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