Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159476734> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2159476734 endingPage "315" @default.
- W2159476734 startingPage "315" @default.
- W2159476734 abstract "When chloramphenicol was incubated with rat liver microsomes, four previously unidentified metabolites were detected and identified. They include chloramphenicol aldehyde (chloramphenicol with the primary alcohol group oxidized to an aldehyde group), p-nitro-benzyl alcohol, N-(2-oxoethyl)dichloroacetamide, and N-(2-hydroxyethyl)dichloroacetamide. The formation of these metabolites was dependent upon the presence of NADPH and O2 and was inhibited when SKF 525-A or CO/O2 (8:2, v/v) were present in the reaction mixture. Moreover, the metabolites were formed by liver microsomes from phenobarbital-treated rats but not by microsomes from untreated rats or rats treated with beta-naphthoflavone. The formation of these metabolites is consistent with a mechanism that involves an initial oxidation of chloramphenicol to chloramphenicol aldehyde by cytochrome P-450. Inasmuch as this metabolite is a beta-hydroxyaldehyde, it can chemically undergo a retro-aldol cleavage to p-nitrobenzaldehyde and N-(2-oxoethyl)dichloroacetamide. Enzymatic reduction of these aldehyde intermediates would yield p-nitrobenzyl alcohol and N-(2-hydroxyethyl)dichloroacetamide, respectively." @default.
- W2159476734 created "2016-06-24" @default.
- W2159476734 creator A5053070558 @default.
- W2159476734 date "1994-03-01" @default.
- W2159476734 modified "2023-09-23" @default.
- W2159476734 title "Robert Bentley Todd (1809-60) and Todd's paralysis." @default.
- W2159476734 doi "https://doi.org/10.1136/jnnp.57.3.315" @default.
- W2159476734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1072820" @default.
- W2159476734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8158178" @default.
- W2159476734 hasPublicationYear "1994" @default.
- W2159476734 type Work @default.
- W2159476734 sameAs 2159476734 @default.
- W2159476734 citedByCount "8" @default.
- W2159476734 countsByYear W21594767342013 @default.
- W2159476734 countsByYear W21594767342017 @default.
- W2159476734 countsByYear W21594767342018 @default.
- W2159476734 countsByYear W21594767342023 @default.
- W2159476734 crossrefType "journal-article" @default.
- W2159476734 hasAuthorship W2159476734A5053070558 @default.
- W2159476734 hasBestOaLocation W21594767341 @default.
- W2159476734 hasConcept C134121241 @default.
- W2159476734 hasConcept C161790260 @default.
- W2159476734 hasConcept C178790620 @default.
- W2159476734 hasConcept C181199279 @default.
- W2159476734 hasConcept C185592680 @default.
- W2159476734 hasConcept C191897082 @default.
- W2159476734 hasConcept C192562407 @default.
- W2159476734 hasConcept C25747580 @default.
- W2159476734 hasConcept C2776460118 @default.
- W2159476734 hasConcept C2776524530 @default.
- W2159476734 hasConcept C2777477808 @default.
- W2159476734 hasConcept C2778473333 @default.
- W2159476734 hasConcept C2779515768 @default.
- W2159476734 hasConcept C2779825165 @default.
- W2159476734 hasConcept C2780263894 @default.
- W2159476734 hasConcept C2780639532 @default.
- W2159476734 hasConcept C2780768313 @default.
- W2159476734 hasConcept C2781066024 @default.
- W2159476734 hasConcept C2781306241 @default.
- W2159476734 hasConcept C501593827 @default.
- W2159476734 hasConcept C55493867 @default.
- W2159476734 hasConcept C61156836 @default.
- W2159476734 hasConcept C71240020 @default.
- W2159476734 hasConcept C87644729 @default.
- W2159476734 hasConceptScore W2159476734C134121241 @default.
- W2159476734 hasConceptScore W2159476734C161790260 @default.
- W2159476734 hasConceptScore W2159476734C178790620 @default.
- W2159476734 hasConceptScore W2159476734C181199279 @default.
- W2159476734 hasConceptScore W2159476734C185592680 @default.
- W2159476734 hasConceptScore W2159476734C191897082 @default.
- W2159476734 hasConceptScore W2159476734C192562407 @default.
- W2159476734 hasConceptScore W2159476734C25747580 @default.
- W2159476734 hasConceptScore W2159476734C2776460118 @default.
- W2159476734 hasConceptScore W2159476734C2776524530 @default.
- W2159476734 hasConceptScore W2159476734C2777477808 @default.
- W2159476734 hasConceptScore W2159476734C2778473333 @default.
- W2159476734 hasConceptScore W2159476734C2779515768 @default.
- W2159476734 hasConceptScore W2159476734C2779825165 @default.
- W2159476734 hasConceptScore W2159476734C2780263894 @default.
- W2159476734 hasConceptScore W2159476734C2780639532 @default.
- W2159476734 hasConceptScore W2159476734C2780768313 @default.
- W2159476734 hasConceptScore W2159476734C2781066024 @default.
- W2159476734 hasConceptScore W2159476734C2781306241 @default.
- W2159476734 hasConceptScore W2159476734C501593827 @default.
- W2159476734 hasConceptScore W2159476734C55493867 @default.
- W2159476734 hasConceptScore W2159476734C61156836 @default.
- W2159476734 hasConceptScore W2159476734C71240020 @default.
- W2159476734 hasConceptScore W2159476734C87644729 @default.
- W2159476734 hasIssue "3" @default.
- W2159476734 hasLocation W21594767341 @default.
- W2159476734 hasLocation W21594767342 @default.
- W2159476734 hasLocation W21594767343 @default.
- W2159476734 hasLocation W21594767344 @default.
- W2159476734 hasOpenAccess W2159476734 @default.
- W2159476734 hasPrimaryLocation W21594767341 @default.
- W2159476734 hasRelatedWork W1967733236 @default.
- W2159476734 hasRelatedWork W1974165727 @default.
- W2159476734 hasRelatedWork W2004241245 @default.
- W2159476734 hasRelatedWork W2006537063 @default.
- W2159476734 hasRelatedWork W2061077446 @default.
- W2159476734 hasRelatedWork W2065261129 @default.
- W2159476734 hasRelatedWork W2086661480 @default.
- W2159476734 hasRelatedWork W2140914755 @default.
- W2159476734 hasRelatedWork W2400152902 @default.
- W2159476734 hasRelatedWork W2429503874 @default.
- W2159476734 hasVolume "57" @default.
- W2159476734 isParatext "false" @default.
- W2159476734 isRetracted "false" @default.
- W2159476734 magId "2159476734" @default.
- W2159476734 workType "article" @default.