Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159545665> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2159545665 endingPage "G17" @default.
- W2159545665 startingPage "G14" @default.
- W2159545665 abstract "The TRITON-TIMI 38 study tested the hypothesis that prasugrel compared with clopidogrel is more efficacious in prevention of ischaemic events in patients undergoing percutaneous coronary intervention (PCI) for either ST-elevation myocardial infarction or for non-ST-elevation acute coronary syndromes. In a double-blind design, 13 608 patients were randomly assigned to receive prasugrel or clopidogrel. During 15-month follow-up, prasugrel compared with clopidogrel significantly reduced the incidence of the primary endpoint, the composite of the rate of cardiovascular death, myocardial infarction, or stroke from 12.1 to 9.9% (hazard ratio: 0.81; P < 0.001). Significant benefit of prasugrel was found during the first 3 days (hazard ratio: 0.82; P = 0.01) and from day 4 to the end of the study (hazard ratio: 0.8; P = 0.003). Of the patients treated with prasugrel, 2.4% experienced at least one TIMI major haemorrhage unrelated to coronary artery bypass graft, compared with 1.8% treated with clopidogrel (hazard ratio: 1.32; P = 0.03). Thus, in the entire study group, the balance of efficacy and safety was in favour of prasugrel with an absolute 2.2% reduction in the primary efficacy endpoint by prasugrel when compared with clopidogrel that was opposed by an only 0.6% increase in major haemorrhage. In conclusion, in patients with acute coronary syndromes undergoing PCI prasugrel significantly reduced the incidence of ischaemic events, both in the acute and long term. Prasugrel was associated with an increased risk of bleeding. In the entire cohort, the superior efficacy of prasugrel outweighed the increased risk of bleeding." @default.
- W2159545665 created "2016-06-24" @default.
- W2159545665 creator A5089531887 @default.
- W2159545665 date "2009-11-24" @default.
- W2159545665 modified "2023-10-18" @default.
- W2159545665 title "Balancing efficacy and safety in the TRITON-TIMI 38 trial" @default.
- W2159545665 cites W1984368932 @default.
- W2159545665 cites W2021241943 @default.
- W2159545665 cites W2048615527 @default.
- W2159545665 cites W2110108344 @default.
- W2159545665 cites W2122962595 @default.
- W2159545665 cites W2138058610 @default.
- W2159545665 cites W2146453185 @default.
- W2159545665 cites W2152823642 @default.
- W2159545665 cites W2169387542 @default.
- W2159545665 doi "https://doi.org/10.1093/eurheartj/sup037" @default.
- W2159545665 hasPublicationYear "2009" @default.
- W2159545665 type Work @default.
- W2159545665 sameAs 2159545665 @default.
- W2159545665 citedByCount "5" @default.
- W2159545665 countsByYear W21595456652013 @default.
- W2159545665 countsByYear W21595456652016 @default.
- W2159545665 countsByYear W21595456652018 @default.
- W2159545665 crossrefType "journal-article" @default.
- W2159545665 hasAuthorship W2159545665A5089531887 @default.
- W2159545665 hasBestOaLocation W21595456651 @default.
- W2159545665 hasConcept C126322002 @default.
- W2159545665 hasConcept C164705383 @default.
- W2159545665 hasConcept C168563851 @default.
- W2159545665 hasConcept C203092338 @default.
- W2159545665 hasConcept C207103383 @default.
- W2159545665 hasConcept C2777028646 @default.
- W2159545665 hasConcept C2777849778 @default.
- W2159545665 hasConcept C2777995511 @default.
- W2159545665 hasConcept C2780400711 @default.
- W2159545665 hasConcept C44249647 @default.
- W2159545665 hasConcept C45393284 @default.
- W2159545665 hasConcept C500558357 @default.
- W2159545665 hasConcept C71924100 @default.
- W2159545665 hasConceptScore W2159545665C126322002 @default.
- W2159545665 hasConceptScore W2159545665C164705383 @default.
- W2159545665 hasConceptScore W2159545665C168563851 @default.
- W2159545665 hasConceptScore W2159545665C203092338 @default.
- W2159545665 hasConceptScore W2159545665C207103383 @default.
- W2159545665 hasConceptScore W2159545665C2777028646 @default.
- W2159545665 hasConceptScore W2159545665C2777849778 @default.
- W2159545665 hasConceptScore W2159545665C2777995511 @default.
- W2159545665 hasConceptScore W2159545665C2780400711 @default.
- W2159545665 hasConceptScore W2159545665C44249647 @default.
- W2159545665 hasConceptScore W2159545665C45393284 @default.
- W2159545665 hasConceptScore W2159545665C500558357 @default.
- W2159545665 hasConceptScore W2159545665C71924100 @default.
- W2159545665 hasIssue "Suppl G" @default.
- W2159545665 hasLocation W21595456651 @default.
- W2159545665 hasOpenAccess W2159545665 @default.
- W2159545665 hasPrimaryLocation W21595456651 @default.
- W2159545665 hasRelatedWork W2127687375 @default.
- W2159545665 hasRelatedWork W2319779375 @default.
- W2159545665 hasRelatedWork W2347602860 @default.
- W2159545665 hasRelatedWork W2355614377 @default.
- W2159545665 hasRelatedWork W2372154413 @default.
- W2159545665 hasRelatedWork W2374929624 @default.
- W2159545665 hasRelatedWork W2375584960 @default.
- W2159545665 hasRelatedWork W2531256647 @default.
- W2159545665 hasRelatedWork W3178172496 @default.
- W2159545665 hasRelatedWork W4385416086 @default.
- W2159545665 hasVolume "11" @default.
- W2159545665 isParatext "false" @default.
- W2159545665 isRetracted "false" @default.
- W2159545665 magId "2159545665" @default.
- W2159545665 workType "article" @default.