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• W2159564650 abstract "Increases in intracellular concentrations of potassium ([K+]i) and sodium ([Na+]i) occur concomitantly with cytopathic effects induced in a CD4+ T-lymphoblastoid cell line acutely infected by human immunodeficiency virus (HIV). This [K+]i increase was greater in cells infected by cytopathic HIV strains than in cells infected by less cytopathic strains. T cells persistently infected by HIV had an increased [K+]i but displayed an [Na+]i similar to that of mock-infected cells. HIV induced increases in [K+]i and [Na+]i after cytopathic infection of human peripheral blood mononuclear cells, but the magnitude of the Na+ changes did not correlate with the extent of the cytopathic effect. Enhanced movement of cations may osmotically drive water entry, resulting in balloon degeneration and lysis of HIV-infected cells. These observations offer potential approaches for antiviral therapies." @default.
• W2159564650 created "2016-06-24" @default.
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• W2159564650 date "1996-08-01" @default.
• W2159564650 modified "2023-10-11" @default.
• W2159564650 title "Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus" @default.
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• W2159564650 doi "https://doi.org/10.1128/jvi.70.8.5447-5454.1996" @default.
• W2159564650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190502" @default.
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