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• W2159567180 abstract "Objective: Alcoholic extract of leaves of Leucas Aspera was tested for anti-inflammatory activity in animal models. Methods: Three doses, 100 mg/kg, 200 mg/kg and 4 00 mg/kg of the plant e xtract prepared as a suspension in 1% tween 80 in normal saline. The control group received only Tween 80 (2%, v/v) orally . Acute and sub - acute inflammatory activities were studied in rats by ca rrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was diclofenac 15 0 mg/kg. Results: All the three test doses (100mg/kg, 200mg/kg,400mg/kg) at different time intervals(0 - 4 hours) did exhibit anti- nflammatory activity in both models ie. Carrageenan model and cotton pellet granuloma model in comparison to control.The test dose of 400mg/kg of leucas aspera produced a percentage inhibition of 60.64%which was comparable to standard drug Diclofenac which produced a percentage inhibition of 60.70% in carrageenan model, whilst the percentage inhibition by cotton pellet method for standard drug was 60.27% and for three different doses of test (100,200,400mg/kg) was 50.85%,57.63%, and 58.42% respectively. Conclusion: Leucas Aspera possesses significant anti- inflammatory activity with p value (0.0001)." @default.
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• W2159567180 date "2014-01-01" @default.
• W2159567180 modified "2023-10-02" @default.
• W2159567180 title "Evaluation of Anti-inflammatory Activity of Alcoholic Extract of Leaves of Leucas Aspera in Albino Rats" @default.
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