FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159577277> ?p ?o ?g. }

• W2159577277 endingPage "2413" @default.
• W2159577277 startingPage "2399" @default.
• W2159577277 abstract "Simple sequence repeats (SSRs) are indel mutational hotspots in genomes. In prokaryotes, SSR loci can cause phase variation, a microbial survival strategy that relies on stochastic, reversible on–off switching of gene activity. By analyzing multiple strains of 42 fully sequenced prokaryotic species, we measure the relative variability and density distribution of SSRs in coding regions. We demonstrate that repeat type strongly influences indel mutation rates, and that the most mutable types are most strongly avoided across genomes. We thoroughly characterize SSR density and variability as a function of N→C position along protein sequences. Using codon-shuffling algorithms that preserve amino acid sequence, we assess evolutionary pressures on SSRs. We find that coding sequences suppress repeats in the middle of proteins, and enrich repeats near termini, yielding U-shaped SSR density curves. We show that for many species this characteristic shape can be attributed to purely biophysical constraints of protein structure. In multiple cases, however, particularly in certain pathogenic bacteria, we observe over enrichment of SSRs near protein N-termini significantly beyond expectation based on structural constraints. This increases the probability that frameshifts result in non-functional proteins, revealing that these species may evolutionarily tune SSR positions in coding regions to facilitate phase variation." @default.
• W2159577277 created "2016-06-24" @default.
• W2159577277 creator A5022604221 @default.
• W2159577277 creator A5031609341 @default.
• W2159577277 date "2011-11-26" @default.
• W2159577277 modified "2023-10-12" @default.
• W2159577277 title "Evolutionary pressures on simple sequence repeats in prokaryotic coding regions" @default.
• W2159577277 cites W1501132333 @default.
• W2159577277 cites W1533331354 @default.
• W2159577277 cites W1965975446 @default.
• W2159577277 cites W1977278056 @default.
• W2159577277 cites W1980237810 @default.
• W2159577277 cites W1985370670 @default.
• W2159577277 cites W1988704611 @default.
• W2159577277 cites W1992344680 @default.
• W2159577277 cites W1997352668 @default.
• W2159577277 cites W2002596897 @default.
• W2159577277 cites W2014061331 @default.
• W2159577277 cites W2018248334 @default.
• W2159577277 cites W2020317941 @default.
• W2159577277 cites W2022023591 @default.
• W2159577277 cites W2026575204 @default.
• W2159577277 cites W2030919957 @default.
• W2159577277 cites W2032414175 @default.
• W2159577277 cites W2035093543 @default.
• W2159577277 cites W2035791573 @default.
• W2159577277 cites W2039403461 @default.
• W2159577277 cites W2043257091 @default.
• W2159577277 cites W2043487490 @default.
• W2159577277 cites W2049435734 @default.
• W2159577277 cites W2054017637 @default.
• W2159577277 cites W2059425839 @default.
• W2159577277 cites W2074539100 @default.
• W2159577277 cites W2080399262 @default.
• W2159577277 cites W2080892263 @default.
• W2159577277 cites W2084241014 @default.
• W2159577277 cites W2092868778 @default.
• W2159577277 cites W2093720374 @default.
• W2159577277 cites W2094982424 @default.
• W2159577277 cites W2096015757 @default.
• W2159577277 cites W2100658004 @default.
• W2159577277 cites W2101961044 @default.
• W2159577277 cites W2104299483 @default.
• W2159577277 cites W2108528950 @default.
• W2159577277 cites W2111909811 @default.
• W2159577277 cites W2112421940 @default.
• W2159577277 cites W2114411653 @default.
• W2159577277 cites W2114499303 @default.
• W2159577277 cites W2115622704 @default.
• W2159577277 cites W2119114298 @default.
• W2159577277 cites W2123546399 @default.
• W2159577277 cites W2127036769 @default.
• W2159577277 cites W2127240867 @default.
• W2159577277 cites W2130138098 @default.
• W2159577277 cites W2132926880 @default.
• W2159577277 cites W2139295688 @default.
• W2159577277 cites W2148950337 @default.
• W2159577277 cites W2158391627 @default.
• W2159577277 cites W2161283204 @default.
• W2159577277 cites W2163255170 @default.
• W2159577277 cites W2167926054 @default.
• W2159577277 cites W68983961 @default.
• W2159577277 doi "https://doi.org/10.1093/nar/gkr1078" @default.
• W2159577277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3315296" @default.
• W2159577277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22123746" @default.
• W2159577277 hasPublicationYear "2011" @default.
• W2159577277 type Work @default.
• W2159577277 sameAs 2159577277 @default.
• W2159577277 citedByCount "64" @default.
• W2159577277 countsByYear W21595772772012 @default.
• W2159577277 countsByYear W21595772772013 @default.
• W2159577277 countsByYear W21595772772014 @default.
• W2159577277 countsByYear W21595772772015 @default.
• W2159577277 countsByYear W21595772772016 @default.
• W2159577277 countsByYear W21595772772017 @default.
• W2159577277 countsByYear W21595772772018 @default.
• W2159577277 countsByYear W21595772772019 @default.
• W2159577277 countsByYear W21595772772020 @default.
• W2159577277 countsByYear W21595772772021 @default.
• W2159577277 countsByYear W21595772772022 @default.
• W2159577277 countsByYear W21595772772023 @default.
• W2159577277 crossrefType "journal-article" @default.
• W2159577277 hasAuthorship W2159577277A5022604221 @default.
• W2159577277 hasAuthorship W2159577277A5031609341 @default.
• W2159577277 hasBestOaLocation W21595772771 @default.
• W2159577277 hasConcept C104317684 @default.
• W2159577277 hasConcept C119054055 @default.
• W2159577277 hasConcept C135763542 @default.
• W2159577277 hasConcept C141231307 @default.
• W2159577277 hasConcept C153209595 @default.
• W2159577277 hasConcept C167625842 @default.
• W2159577277 hasConcept C167927819 @default.
• W2159577277 hasConcept C199216141 @default.
• W2159577277 hasConcept C199360897 @default.
• W2159577277 hasConcept C2910714999 @default.
• W2159577277 hasConcept C29511175 @default.
• W2159577277 hasConcept C41008148 @default.
• W2159577277 hasConcept C45484198 @default.

• next