FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159578510> ?p ?o ?g. }

• W2159578510 endingPage "213" @default.
• W2159578510 startingPage "206" @default.
• W2159578510 abstract "LINE-1 (L1) retrotransposons constitute the most successful family of autonomous retroelements in mammals and they represent at least 17% of the size of the human genome. L1 insertions have occasionally been recruited to perform a beneficial function but the vast majority of L1 inserts are either neutral or deleterious. The basis for the deleterious effect of L1 remains a matter of debate and three possible mechanisms have been suggested: the direct effect of L1 inserts on gene activity, genetic rearrangements caused by L1-mediated ectopic recombination, or the retrotransposition process per se. We performed a genome-wide analysis of the distribution of L1 retrotransposons relative to the local recombination rate and the age and length of the elements. The proportion of L1 elements that are longer than 1.2 Kb is higher in low-recombining regions of the genome than in regions with a high recombination rate, but the genomic distributions of full-length elements (i.e. elements capable of retrotransposition) and long truncated elements were indistinguishable. We also found that the intensity of selection against long elements is proportional to the replicative success of L1 families. This suggests that the deleterious effect of L1 elements results principally from their ability to mediate ectopic recombination." @default.
• W2159578510 created "2016-06-24" @default.
• W2159578510 creator A5082897828 @default.
• W2159578510 creator A5084509179 @default.
• W2159578510 date "2007-04-01" @default.
• W2159578510 modified "2023-10-14" @default.
• W2159578510 title "Selection against LINE-1 retrotransposons results principally from their ability to mediate ectopic recombination" @default.
• W2159578510 cites W1689369637 @default.
• W2159578510 cites W1798060291 @default.
• W2159578510 cites W1970218405 @default.
• W2159578510 cites W1976272331 @default.
• W2159578510 cites W1981262837 @default.
• W2159578510 cites W1987332588 @default.
• W2159578510 cites W1987882116 @default.
• W2159578510 cites W1991719330 @default.
• W2159578510 cites W1996177514 @default.
• W2159578510 cites W1997724443 @default.
• W2159578510 cites W1998026277 @default.
• W2159578510 cites W2005877477 @default.
• W2159578510 cites W2028035241 @default.
• W2159578510 cites W2038378062 @default.
• W2159578510 cites W2050557699 @default.
• W2159578510 cites W2054143743 @default.
• W2159578510 cites W2054236386 @default.
• W2159578510 cites W2055873867 @default.
• W2159578510 cites W2062098224 @default.
• W2159578510 cites W2068563598 @default.
• W2159578510 cites W2081293476 @default.
• W2159578510 cites W2099949533 @default.
• W2159578510 cites W2104743461 @default.
• W2159578510 cites W2113300865 @default.
• W2159578510 cites W2117190061 @default.
• W2159578510 cites W2122009637 @default.
• W2159578510 cites W2129449099 @default.
• W2159578510 cites W2130315111 @default.
• W2159578510 cites W2133277576 @default.
• W2159578510 cites W2138790911 @default.
• W2159578510 cites W2139477052 @default.
• W2159578510 cites W2144121185 @default.
• W2159578510 cites W2147095088 @default.
• W2159578510 cites W2151464048 @default.
• W2159578510 cites W2153586836 @default.
• W2159578510 cites W2163786692 @default.
• W2159578510 cites W2168909179 @default.
• W2159578510 cites W2266704567 @default.
• W2159578510 cites W2284756847 @default.
• W2159578510 cites W4232591682 @default.
• W2159578510 cites W4245633586 @default.
• W2159578510 cites W4242574543 @default.
• W2159578510 doi "https://doi.org/10.1016/j.gene.2006.09.033" @default.
• W2159578510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17134851" @default.
• W2159578510 hasPublicationYear "2007" @default.
• W2159578510 type Work @default.
• W2159578510 sameAs 2159578510 @default.
• W2159578510 citedByCount "67" @default.
• W2159578510 countsByYear W21595785102012 @default.
• W2159578510 countsByYear W21595785102013 @default.
• W2159578510 countsByYear W21595785102014 @default.
• W2159578510 countsByYear W21595785102015 @default.
• W2159578510 countsByYear W21595785102016 @default.
• W2159578510 countsByYear W21595785102017 @default.
• W2159578510 countsByYear W21595785102018 @default.
• W2159578510 countsByYear W21595785102019 @default.
• W2159578510 countsByYear W21595785102020 @default.
• W2159578510 countsByYear W21595785102021 @default.
• W2159578510 countsByYear W21595785102022 @default.
• W2159578510 countsByYear W21595785102023 @default.
• W2159578510 crossrefType "journal-article" @default.
• W2159578510 hasAuthorship W2159578510A5082897828 @default.
• W2159578510 hasAuthorship W2159578510A5084509179 @default.
• W2159578510 hasConcept C101434241 @default.
• W2159578510 hasConcept C102744134 @default.
• W2159578510 hasConcept C104317684 @default.
• W2159578510 hasConcept C141231307 @default.
• W2159578510 hasConcept C154945302 @default.
• W2159578510 hasConcept C156695909 @default.
• W2159578510 hasConcept C41008148 @default.
• W2159578510 hasConcept C4918238 @default.
• W2159578510 hasConcept C50919411 @default.
• W2159578510 hasConcept C54355233 @default.
• W2159578510 hasConcept C7029365 @default.
• W2159578510 hasConcept C7386963 @default.
• W2159578510 hasConcept C81917197 @default.
• W2159578510 hasConcept C86803240 @default.
• W2159578510 hasConceptScore W2159578510C101434241 @default.
• W2159578510 hasConceptScore W2159578510C102744134 @default.
• W2159578510 hasConceptScore W2159578510C104317684 @default.
• W2159578510 hasConceptScore W2159578510C141231307 @default.
• W2159578510 hasConceptScore W2159578510C154945302 @default.
• W2159578510 hasConceptScore W2159578510C156695909 @default.
• W2159578510 hasConceptScore W2159578510C41008148 @default.
• W2159578510 hasConceptScore W2159578510C4918238 @default.
• W2159578510 hasConceptScore W2159578510C50919411 @default.
• W2159578510 hasConceptScore W2159578510C54355233 @default.
• W2159578510 hasConceptScore W2159578510C7029365 @default.
• W2159578510 hasConceptScore W2159578510C7386963 @default.
• W2159578510 hasConceptScore W2159578510C81917197 @default.
• W2159578510 hasConceptScore W2159578510C86803240 @default.

• next