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• W2159579272 startingPage "833" @default.
• W2159579272 abstract "Prolonged hyperglycaemia impairs vascular reactivity and inhibits voltage‐activated K + (Kv) channels. We examined acute effects of altering glucose concentration on the activity and inhibition by endothelin‐1 (ET‐1) of Kv currents of freshly isolated rat arterial myocytes. Peak Kv currents recorded in glucose‐free solution were reversibly reduced within 200 s by increasing extracellular glucose to 4 m m . This inhibitory effect of glucose was abolished by protein kinase C inhibitor peptide (PKC‐IP), and Kv currents were further reduced in 10 m m glucose. In current‐clamped cells, membrane potentials were more negative in 4 than in 10 m m glucose. In 4 m m d ‐glucose, 10 n m ET‐1 decreased peak Kv current amplitude at +60 mV from 23.5 ± 3.3 to 12.1 ± 3.1 pA pF −1 ( n = 6, P < 0.001) and increased the rate of inactivation, decreasing the time constant around fourfold. Inhibition by ET‐1 was prevented by PKC‐IP. When d ‐glucose was increased to 10 m m , ET‐1 no longer inhibited Kv current ( n = 6). Glucose metabolism was required for prevention of ET‐1 inhibition of Kv currents, since fructose mimicked the effects of d ‐glucose, while l ‐glucose, sucrose or mannitol were without effect. Endothelin receptors were still functional in 10 m m d ‐glucose, since pinacidil‐activated ATP‐dependent K + (K ATP ) currents were reduced by 10 n m ET‐1. This inhibition was nearly abolished by PKC‐IP, indicating that endothelin receptors could still activate PKC in 10 m m d ‐glucose. These results indicate that changes in extracellular glucose concentration within the physiological range can reduce Kv current amplitude and can have major effects on Kv channel modulation by vasoconstrictors." @default.
• W2159579272 created "2016-06-24" @default.
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• W2159579272 date "2006-09-06" @default.
• W2159579272 modified "2023-10-18" @default.
• W2159579272 title "Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells" @default.
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• W2159579272 doi "https://doi.org/10.1113/jphysiol.2006.114009" @default.
• W2159579272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995678" @default.
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