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- W2159606670 abstract "More than a decade after West Nile virus (WNV) entered North America, and despite a significant increase in reported cases during the 2012 and 2013 seasons, no treatment or vaccine for humans is available. Although antiviral T cells contribute to the control of WNV, little is known about their regulation during acute infection. We analyzed the expression of Tim-3 and PD-1, two recently identified T cell negative immune checkpoint receptors, over the course of WNV infection. Symptomatic WNV+ donors exhibited higher frequencies of Tim-3+ cells than asymptomatic subjects within naïve/early differentiated CD28+/-CD57-CD4+ and differentiated CD28-CD57-CD8+ T cells. Our study links Tim-3-expression on T cells during acute WNV infection with the development of symptomatic disease, suggesting Tim-3 and its ligands could be targeted therapeutically to alter anti-WNV immunity and improve disease outcome." @default.
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- W2159606670 date "2014-03-18" @default.
- W2159606670 modified "2023-10-05" @default.
- W2159606670 title "Increased Frequency of Tim-3 Expressing T Cells Is Associated with Symptomatic West Nile Virus Infection" @default.
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- W2159606670 doi "https://doi.org/10.1371/journal.pone.0092134" @default.
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