Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159631773> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2159631773 endingPage "219" @default.
- W2159631773 startingPage "219" @default.
- W2159631773 abstract "1. The effect of the administration of oestrone sulphate on tryptophan metabolism has been assessed in rats in order to determine whether and to what extent inhibition of tryptophan metabolism by oestrogens may be a factor in the aetiology of pellagra, and might explain the reported twofold excess of females over males in many outbreaks of pellagra.2. Feeding ovariectomized rats for 1 week on a diet containing 15 mg oestrone sulphate/kg led to significant inhibition of kynurenine hydroxylase (EC 1.14.13.9), kynureninase (EC 3.7.1.3) and 3-hydroxyanthranilate oxidase (EC 1.13.11.6). There was also a significant increase in plasma tryptophan, suggesting decreased activity of tryptophan oxygenase (EC 1.13.11.11). This inhibition of tryptophan metabolism will result in a considerable reduction in the synthesis of the nicotinamide nucleotide coenzymes (NAD and NADP) from tryptophan.3. When ovariectomized rats were maintained for 4 weeks on a diet providing no preformed niacin and only a marginally adequate amount of tryptophan (1030 mg/kg), the addition of oestrone sulphate to the diet led to a significant reduction in the liver content of nicotinamide nucleotides and the urinary excretion of the end-product of NAD metabolism, N1-methyl nicotinamide.4. It is suggested that when the diet is only marginally adequate in tryptophan and niacin, inhibition of tryptophan metabolism by endogenous or administered oestrogens may be an additional factor in the development of pellagra." @default.
- W2159631773 created "2016-06-24" @default.
- W2159631773 creator A5004994385 @default.
- W2159631773 creator A5081969877 @default.
- W2159631773 date "1984-03-01" @default.
- W2159631773 modified "2023-10-16" @default.
- W2159631773 title "Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra" @default.
- W2159631773 cites W167675933 @default.
- W2159631773 cites W1821550886 @default.
- W2159631773 cites W184980440 @default.
- W2159631773 cites W1967920770 @default.
- W2159631773 cites W1975148473 @default.
- W2159631773 cites W1982530042 @default.
- W2159631773 cites W2030331367 @default.
- W2159631773 cites W2077550843 @default.
- W2159631773 cites W2086336720 @default.
- W2159631773 cites W2091588936 @default.
- W2159631773 cites W2114083878 @default.
- W2159631773 cites W2114823502 @default.
- W2159631773 cites W2137913607 @default.
- W2159631773 cites W305167232 @default.
- W2159631773 cites W4253131441 @default.
- W2159631773 doi "https://doi.org/10.1079/bjn19840026" @default.
- W2159631773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6231048" @default.
- W2159631773 hasPublicationYear "1984" @default.
- W2159631773 type Work @default.
- W2159631773 sameAs 2159631773 @default.
- W2159631773 citedByCount "24" @default.
- W2159631773 countsByYear W21596317732012 @default.
- W2159631773 countsByYear W21596317732016 @default.
- W2159631773 countsByYear W21596317732017 @default.
- W2159631773 countsByYear W21596317732018 @default.
- W2159631773 countsByYear W21596317732019 @default.
- W2159631773 crossrefType "journal-article" @default.
- W2159631773 hasAuthorship W2159631773A5004994385 @default.
- W2159631773 hasAuthorship W2159631773A5081969877 @default.
- W2159631773 hasBestOaLocation W21596317731 @default.
- W2159631773 hasConcept C126322002 @default.
- W2159631773 hasConcept C134018914 @default.
- W2159631773 hasConcept C181199279 @default.
- W2159631773 hasConcept C185592680 @default.
- W2159631773 hasConcept C2776706248 @default.
- W2159631773 hasConcept C2777503454 @default.
- W2159631773 hasConcept C2779439245 @default.
- W2159631773 hasConcept C2779728014 @default.
- W2159631773 hasConcept C2780092750 @default.
- W2159631773 hasConcept C515207424 @default.
- W2159631773 hasConcept C55493867 @default.
- W2159631773 hasConcept C62231903 @default.
- W2159631773 hasConcept C71924100 @default.
- W2159631773 hasConcept C75520062 @default.
- W2159631773 hasConcept C86803240 @default.
- W2159631773 hasConceptScore W2159631773C126322002 @default.
- W2159631773 hasConceptScore W2159631773C134018914 @default.
- W2159631773 hasConceptScore W2159631773C181199279 @default.
- W2159631773 hasConceptScore W2159631773C185592680 @default.
- W2159631773 hasConceptScore W2159631773C2776706248 @default.
- W2159631773 hasConceptScore W2159631773C2777503454 @default.
- W2159631773 hasConceptScore W2159631773C2779439245 @default.
- W2159631773 hasConceptScore W2159631773C2779728014 @default.
- W2159631773 hasConceptScore W2159631773C2780092750 @default.
- W2159631773 hasConceptScore W2159631773C515207424 @default.
- W2159631773 hasConceptScore W2159631773C55493867 @default.
- W2159631773 hasConceptScore W2159631773C62231903 @default.
- W2159631773 hasConceptScore W2159631773C71924100 @default.
- W2159631773 hasConceptScore W2159631773C75520062 @default.
- W2159631773 hasConceptScore W2159631773C86803240 @default.
- W2159631773 hasIssue "02" @default.
- W2159631773 hasLocation W21596317731 @default.
- W2159631773 hasLocation W21596317732 @default.
- W2159631773 hasLocation W21596317733 @default.
- W2159631773 hasLocation W21596317734 @default.
- W2159631773 hasOpenAccess W2159631773 @default.
- W2159631773 hasPrimaryLocation W21596317731 @default.
- W2159631773 hasRelatedWork W2019224474 @default.
- W2159631773 hasRelatedWork W2055000363 @default.
- W2159631773 hasRelatedWork W2101221958 @default.
- W2159631773 hasRelatedWork W2141716092 @default.
- W2159631773 hasRelatedWork W2159631773 @default.
- W2159631773 hasRelatedWork W2171037485 @default.
- W2159631773 hasRelatedWork W2325971639 @default.
- W2159631773 hasRelatedWork W2401656257 @default.
- W2159631773 hasRelatedWork W2588112835 @default.
- W2159631773 hasRelatedWork W4226183357 @default.
- W2159631773 hasVolume "51" @default.
- W2159631773 isParatext "false" @default.
- W2159631773 isRetracted "false" @default.
- W2159631773 magId "2159631773" @default.
- W2159631773 workType "article" @default.