FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159643722> ?p ?o ?g. }

• W2159643722 endingPage "1917" @default.
• W2159643722 startingPage "1908" @default.
• W2159643722 abstract "Elongation factor Tu (EF-Tu), the protein responsible for delivering aminoacyl-tRNAs (aa-tRNAs) to ribosomal A site during translation, belongs to the group of guanosine-nucleotide (GTP/GDP) binding proteins. Its active ‘on’-state corresponds to the GTP-bound form, while the inactive ‘off’-state corresponds to the GDP-bound form. In this work we focus on the chemical step, GTP + H2O → GDP + Pi, of the hydrolysis mechanism. We apply molecular modeling tools including molecular dynamics simulations and the combined quantum mechanical–molecular mechanical calculations for estimates of reaction energy profiles for two possible arrangements of switch II regions of EF-Tu. In the first case we presumably mimic binding of the ternary complex EF-Tu·GTP·aa-tRNA to the ribosome and allow the histidine (His85) side chain of the protein to approach the reaction active site. In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP + H2O → GDP + Pi proceeds without participation of the histidine but through water molecules. In agreement with the experimental observations which distinguish rate constants for the fast chemical reaction in EF-Tu·GTP·aa-tRNA·ribosome and the slow spontaneous GTP hydrolysis in EF-Tu, we show that the activation energy barrier for the first scenario is considerably lower compared to that of the second case." @default.
• W2159643722 created "2016-06-24" @default.
• W2159643722 creator A5027040934 @default.
• W2159643722 creator A5029122049 @default.
• W2159643722 creator A5039655135 @default.
• W2159643722 creator A5040834337 @default.
• W2159643722 creator A5074996596 @default.
• W2159643722 date "2008-12-01" @default.
• W2159643722 modified "2023-10-07" @default.
• W2159643722 title "Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu" @default.
• W2159643722 cites W1546721600 @default.
• W2159643722 cites W1903181902 @default.
• W2159643722 cites W1918945878 @default.
• W2159643722 cites W1968010838 @default.
• W2159643722 cites W1970291721 @default.
• W2159643722 cites W1971564045 @default.
• W2159643722 cites W1975845692 @default.
• W2159643722 cites W1976360756 @default.
• W2159643722 cites W1978717578 @default.
• W2159643722 cites W1982144407 @default.
• W2159643722 cites W1988269915 @default.
• W2159643722 cites W1991987769 @default.
• W2159643722 cites W1992496730 @default.
• W2159643722 cites W1993466966 @default.
• W2159643722 cites W2001690457 @default.
• W2159643722 cites W2004303971 @default.
• W2159643722 cites W2005189737 @default.
• W2159643722 cites W2019183899 @default.
• W2159643722 cites W2020490407 @default.
• W2159643722 cites W2022950330 @default.
• W2159643722 cites W2024484334 @default.
• W2159643722 cites W2027408247 @default.
• W2159643722 cites W2031178514 @default.
• W2159643722 cites W2031969751 @default.
• W2159643722 cites W2042701134 @default.
• W2159643722 cites W2044490585 @default.
• W2159643722 cites W2051728948 @default.
• W2159643722 cites W2058395728 @default.
• W2159643722 cites W2062788730 @default.
• W2159643722 cites W2076647551 @default.
• W2159643722 cites W2077501220 @default.
• W2159643722 cites W2080902120 @default.
• W2159643722 cites W2085061189 @default.
• W2159643722 cites W2089775448 @default.
• W2159643722 cites W2093055699 @default.
• W2159643722 cites W2097909552 @default.
• W2159643722 cites W2100061812 @default.
• W2159643722 cites W2103815459 @default.
• W2159643722 cites W2111406267 @default.
• W2159643722 cites W2114460420 @default.
• W2159643722 cites W2118391959 @default.
• W2159643722 cites W2122028042 @default.
• W2159643722 cites W2122199548 @default.
• W2159643722 cites W2130479394 @default.
• W2159643722 cites W2150779201 @default.
• W2159643722 cites W2162166182 @default.
• W2159643722 cites W2166295365 @default.
• W2159643722 cites W2167486610 @default.
• W2159643722 doi "https://doi.org/10.1016/j.bbapap.2008.08.003" @default.
• W2159643722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2621105" @default.
• W2159643722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18773979" @default.
• W2159643722 hasPublicationYear "2008" @default.
• W2159643722 type Work @default.
• W2159643722 sameAs 2159643722 @default.
• W2159643722 citedByCount "24" @default.
• W2159643722 countsByYear W21596437222012 @default.
• W2159643722 countsByYear W21596437222013 @default.
• W2159643722 countsByYear W21596437222014 @default.
• W2159643722 countsByYear W21596437222015 @default.
• W2159643722 countsByYear W21596437222016 @default.
• W2159643722 crossrefType "journal-article" @default.
• W2159643722 hasAuthorship W2159643722A5027040934 @default.
• W2159643722 hasAuthorship W2159643722A5029122049 @default.
• W2159643722 hasAuthorship W2159643722A5039655135 @default.
• W2159643722 hasAuthorship W2159643722A5040834337 @default.
• W2159643722 hasAuthorship W2159643722A5074996596 @default.
• W2159643722 hasBestOaLocation W21596437222 @default.
• W2159643722 hasConcept C104317684 @default.
• W2159643722 hasConcept C118716 @default.
• W2159643722 hasConcept C139124968 @default.
• W2159643722 hasConcept C181199279 @default.
• W2159643722 hasConcept C185592680 @default.
• W2159643722 hasConcept C207332259 @default.
• W2159643722 hasConcept C2776638253 @default.
• W2159643722 hasConcept C2777995097 @default.
• W2159643722 hasConcept C2779817904 @default.
• W2159643722 hasConcept C512185932 @default.
• W2159643722 hasConcept C55493867 @default.
• W2159643722 hasConcept C67705224 @default.
• W2159643722 hasConcept C71240020 @default.
• W2159643722 hasConcept C75442077 @default.
• W2159643722 hasConcept C8010536 @default.
• W2159643722 hasConcept C88478588 @default.
• W2159643722 hasConceptScore W2159643722C104317684 @default.
• W2159643722 hasConceptScore W2159643722C118716 @default.
• W2159643722 hasConceptScore W2159643722C139124968 @default.
• W2159643722 hasConceptScore W2159643722C181199279 @default.
• W2159643722 hasConceptScore W2159643722C185592680 @default.

• next