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• W2159645830 startingPage "838" @default.
• W2159645830 abstract "Mouse oocytes undergo polarization during meiotic maturation, and this polarization is essential for asymmetric cell divisions that maximize retention of maternal components required for early development. Without conventional centrosomes, the meiotic spindle has less focused poles and is barrel-shaped. The migration of meiotic spindles to the cortex is accompanied by a local reorganization and polarization of the cortex. LGN is a conserved protein involved in cell polarity and regulation of spindle organization. In the present study, we characterized the localization dynamics of LGN during mouse oocyte maturation and analyzed the effects of LGN upregulation and downregulation on meiotic spindle organization. At the germinal vesicle stage, LGN is distributed both cytoplasmically and at the cortex. During maturation, LGN localizes to the meiotic spindle apparatus and cortical LGN becomes less concentrated at the actin cap region. Excessive LGN induces meiotic spindle organization defects by elongating the spindle and enhancing pole focusing, whereas depletion of LGN by RNA interference results in meiotic spindle deformation and chromosome misalignment. Furthermore, the N-terminus of LGN has the ability of full-length LGN to regulate spindle organization, whereas the C-terminus of LGN controls cortical localization and polarization. Our results reveal that LGN is cortically polarized in mouse oocytes and is critical for meiotic spindle organization." @default.
• W2159645830 created "2016-06-24" @default.
• W2159645830 creator A5058603003 @default.
• W2159645830 creator A5086335081 @default.
• W2159645830 date "2009-05-12" @default.
• W2159645830 modified "2023-10-09" @default.
• W2159645830 title "Pins homolog LGN regulates meiotic spindle organization in mouse oocytes" @default.
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• W2159645830 doi "https://doi.org/10.1038/cr.2009.54" @default.
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