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• W2159661453 abstract "Here we demonstrated that sepantronium bromide (YM155), a survivin suppressant, inhibited esophageal squamous-cell carcinoma (ESCC) growth in mice bearing human ESCC xenografts without affecting body weight. In cell culture, YM155 decreased survivin levels and caused PARP-1 activation, poly-ADP polymer formation, and AIF translocation from the cytosol to the nucleus. Genetic knockdown of PARP-1 or AIF abrogated YM155-induced parthanatos cell death. Furthermore, FOS, JUN and c-MYC gene transcription, which is stimulated by activated PARP-1, was increased following YM155 treatment. Our data demonstrate that YM155 did not trigger apoptosis, but induced parthanatos, a cell death dependent on PARP-1 hyper-activation, and support clinical development of YM155 in ESCC." @default.
• W2159661453 created "2016-06-24" @default.
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• W2159661453 date "2015-06-15" @default.
• W2159661453 modified "2023-10-18" @default.
• W2159661453 title "YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice" @default.
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• W2159661453 doi "https://doi.org/10.18632/oncotarget.4315" @default.
• W2159661453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4621902" @default.
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