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- W2159672783 abstract "1 Rats were pithed in order to srupt baroreflex pathways. Heart rate was used as a measure of β1-adrenoceptor activity, blood pressure as a measure of β2-adrenoceptor activity and oxygen consumption and brown adipose tissue temperature as measures of β3-adrenoceptor activity. 2 The effects of the selective β3-adrenoceptor agonist BRL 37344 were compared with those of isoprenaline, a non-selective β -adrenoceptor agonist, and denopamine and salbutamol, which are respectively β1 and β2-adrenoceptor agonists. 3 Denopamine was 10-fold more potent on heart rate than blood pressure, whilst salbutamol was 18-fold more potent on blood pressure than heart rate. These findings confirm that in this preparation increases in heart rate are predominantly β1-adrenoceptor-mediated, whilst blood pressure is β2-adrenoceptor-mediated. Further confirmation is provided by the blockade with atenolol, of the chronotropic effect, but not the blood pressure effect, of isoprenaline. 4 BRL 37344 was the most potent β -adrenoceptor agonist on both oxygen consumption and brown adipose tissue temperature, revealing the β3-nature of these responses. Dose-response curves for oxygen consumption and brown adipose tissue temperature were identical, whichever of the β -adrenoceptor agonists was used. Both systems may be considered equally effective as indicators of β3-adrenoceptor agonist activity." @default.
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- W2159672783 date "1994-10-01" @default.
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- W2159672783 title "The β-adrenoceptor selectivity profile of BRL 37344 in the pithed rat" @default.
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- W2159672783 doi "https://doi.org/10.1111/j.1474-8673.1994.tb00614.x" @default.
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