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• W2159673032 abstract "<b>Background and aims:</b> The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation into the oesophageal mucosa, we measured interstitial pH (pH_int) of the oesophageal basal epithelial layer, pre-epithelial layer thickness, and blood flow in rats in vivo during luminal acid challenge. A novel confocal microscopic technique was used in vitro to measure pH_int from defined cellular sites in response to luminal and basolateral acidification. <b>Methods:</b> 5-(and-6)-Carboxyfluorescein (CF) and carboxy-seminapthorhodofluor-1 (SNARF-1) fluorescence was used to measure pH_int by conventional and confocal microscopy, respectively, in urethane anaesthetised rats. Pre-epithelial layer thickness was measured optically with carbon particles as markers. Blood flow was measured with laser Doppler flowmetry. <b>Results:</b> Luminal acidification failed to alter pH_int in vivo and in vitro, but pH_int was lowered by modest serosal acidification. Pre-epithelial layer thickness and blood flow increased significantly during luminal surface acid perfusion. Indomethacin had no effect on any acid related response. <b>Conclusion:</b> In this first dynamic measurement of oesophageal acid permeation and pre-epithelial layer thickness, pH_int was preserved in spite of high luminal acidity by two complementary techniques. Despite the apparent permeability barrier to acid permeation, oesophageal blood flow and thickness responded to luminal acid perfusion." @default.
• W2159673032 created "2016-06-24" @default.
• W2159673032 creator A5068039010 @default.
• W2159673032 date "2003-06-01" @default.
• W2159673032 modified "2023-10-18" @default.
• W2159673032 title "Direct measurement of acid permeation into rat oesophagus" @default.
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• W2159673032 doi "https://doi.org/10.1136/gut.52.6.775" @default.
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