Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159680569> ?p ?o ?g. }
- W2159680569 endingPage "C722" @default.
- W2159680569 startingPage "C713" @default.
- W2159680569 abstract "The purposes of this study were to determine whether, immediately after lengthening contractions, 1) levels of specific force-transmitting cytoskeletal elements are reduced in skeletal muscle cells and 2) cytosolic small heat shock proteins (HSPs) translocate to structures prone to disruption. Western blot analysis demonstrated decreased concentrations of z-disk proteins α-actinin and plectin and membrane scaffolding proteins dystrophin and β-spectrin in muscle exposed to lengthening contractions compared with contralateral control muscle. Lengthening contractions also resulted in immediate translocation of constitutively expressed HSP25 and αB-crystallin from the soluble to the insoluble fraction of muscle homogenates, and cryosections showed translocation from a diffuse, cytosolic localization to striations that corresponded to z-disks. Lengthening contraction-induced translocation of HSP25 and αB-crystallin was associated with phosphorylation of these small HSPs, which may trigger their protective activity. In summary, these findings demonstrate loss of z-disk and membrane scaffolding proteins immediately after lengthening contractions, and concomitant translocation of HSP25 and αB-crystallin to the z-disk, which may help to stabilize or repair cytoskeletal elements at this site." @default.
- W2159680569 created "2016-06-24" @default.
- W2159680569 creator A5005993605 @default.
- W2159680569 creator A5023434181 @default.
- W2159680569 date "2004-03-01" @default.
- W2159680569 modified "2023-09-27" @default.
- W2159680569 title "Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions" @default.
- W2159680569 cites W1481224391 @default.
- W2159680569 cites W1522004608 @default.
- W2159680569 cites W1540426161 @default.
- W2159680569 cites W1581180757 @default.
- W2159680569 cites W1597721077 @default.
- W2159680569 cites W1866799938 @default.
- W2159680569 cites W1893151759 @default.
- W2159680569 cites W192989869 @default.
- W2159680569 cites W1967778938 @default.
- W2159680569 cites W1968210959 @default.
- W2159680569 cites W1969683573 @default.
- W2159680569 cites W1971272552 @default.
- W2159680569 cites W1980536586 @default.
- W2159680569 cites W1985632088 @default.
- W2159680569 cites W1990004104 @default.
- W2159680569 cites W1991784998 @default.
- W2159680569 cites W2006955286 @default.
- W2159680569 cites W2008359273 @default.
- W2159680569 cites W2028194205 @default.
- W2159680569 cites W2036023681 @default.
- W2159680569 cites W2043832285 @default.
- W2159680569 cites W2048296329 @default.
- W2159680569 cites W2052427726 @default.
- W2159680569 cites W2058140775 @default.
- W2159680569 cites W2059837309 @default.
- W2159680569 cites W2084737793 @default.
- W2159680569 cites W2085054634 @default.
- W2159680569 cites W2088976076 @default.
- W2159680569 cites W2089271830 @default.
- W2159680569 cites W2093625864 @default.
- W2159680569 cites W2096244374 @default.
- W2159680569 cites W2103795143 @default.
- W2159680569 cites W2114331846 @default.
- W2159680569 cites W2123343796 @default.
- W2159680569 cites W2127058444 @default.
- W2159680569 cites W2146629575 @default.
- W2159680569 cites W2154904733 @default.
- W2159680569 cites W2156759248 @default.
- W2159680569 cites W2157059052 @default.
- W2159680569 cites W2189548052 @default.
- W2159680569 cites W2267906346 @default.
- W2159680569 cites W2268491621 @default.
- W2159680569 cites W2292568679 @default.
- W2159680569 cites W4238484915 @default.
- W2159680569 cites W4297573836 @default.
- W2159680569 doi "https://doi.org/10.1152/ajpcell.00341.2003" @default.
- W2159680569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14627610" @default.
- W2159680569 hasPublicationYear "2004" @default.
- W2159680569 type Work @default.
- W2159680569 sameAs 2159680569 @default.
- W2159680569 citedByCount "169" @default.
- W2159680569 countsByYear W21596805692012 @default.
- W2159680569 countsByYear W21596805692013 @default.
- W2159680569 countsByYear W21596805692014 @default.
- W2159680569 countsByYear W21596805692015 @default.
- W2159680569 countsByYear W21596805692016 @default.
- W2159680569 countsByYear W21596805692017 @default.
- W2159680569 countsByYear W21596805692018 @default.
- W2159680569 countsByYear W21596805692019 @default.
- W2159680569 countsByYear W21596805692020 @default.
- W2159680569 countsByYear W21596805692021 @default.
- W2159680569 countsByYear W21596805692022 @default.
- W2159680569 countsByYear W21596805692023 @default.
- W2159680569 crossrefType "journal-article" @default.
- W2159680569 hasAuthorship W2159680569A5005993605 @default.
- W2159680569 hasAuthorship W2159680569A5023434181 @default.
- W2159680569 hasConcept C104317684 @default.
- W2159680569 hasConcept C105702510 @default.
- W2159680569 hasConcept C11960822 @default.
- W2159680569 hasConcept C138626823 @default.
- W2159680569 hasConcept C142669718 @default.
- W2159680569 hasConcept C1491633281 @default.
- W2159680569 hasConcept C181199279 @default.
- W2159680569 hasConcept C185592680 @default.
- W2159680569 hasConcept C205260736 @default.
- W2159680569 hasConcept C2779959927 @default.
- W2159680569 hasConcept C2780394045 @default.
- W2159680569 hasConcept C50244902 @default.
- W2159680569 hasConcept C55493867 @default.
- W2159680569 hasConcept C6997183 @default.
- W2159680569 hasConcept C86803240 @default.
- W2159680569 hasConcept C95444343 @default.
- W2159680569 hasConcept C98539663 @default.
- W2159680569 hasConceptScore W2159680569C104317684 @default.
- W2159680569 hasConceptScore W2159680569C105702510 @default.
- W2159680569 hasConceptScore W2159680569C11960822 @default.
- W2159680569 hasConceptScore W2159680569C138626823 @default.
- W2159680569 hasConceptScore W2159680569C142669718 @default.
- W2159680569 hasConceptScore W2159680569C1491633281 @default.
- W2159680569 hasConceptScore W2159680569C181199279 @default.
- W2159680569 hasConceptScore W2159680569C185592680 @default.