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• W2159683398 abstract "<h3>Objective</h3> To investigate whether interleukin 1β (IL-1β) exon 5 and IL-1 receptor antagonist (IL-1Ra) gene polymorphisms can be used as markers of susceptibility to febrile convulsions in children. <h3>Methods</h3> Children were divided into 2 groups: those with febrile convulsions (group 1; n = 51) and normal control subjects (group 2; n = 83). Polymorphisms for IL-1β exon 5 and IL-1Ra gene polymorphisms were detected by polymerase chain reaction. Genotypes and allelic frequencies for IL-1β exon 5 and IL-1Ra gene polymorphisms in both groups were compared. <h3>Results</h3> Genotype and allele frequencies for IL-1β exon 5 in both groups were not significantly different. Proportions of<i>E1</i>homozygotes and<i>E1/E2</i>heterozygotes for IL-1β exon 5 were 50 (98.1%) and 1 (1.9%), respectively, in group 1 and 82 (98.8%) and 1 (1.2%), respectively, in group 2. Frequencies of alleles<i>E1</i>and<i>E2</i>for IL-1β exon 5 were 101 (99.0%) and 1 (1.0%), respectively, in group 1 and 165 (99.4%) and 1 (0.6%), respectively, in group 2. Genotype proportions and allele frequencies for IL-1Ra between groups were significantly different. Proportions of genotypes<i>I/I</i>and<i>I/II</i>for IL-1Ra were 49 (96.1%) and 2 (3.9%) in group 1 and 69 (83.1%) and 14 (16.9%) in group 2. Frequencies of alleles<i>I</i>and<i>II</i>for IL-1Ra were 100 (98.0%) and 2 (2.0%) in group 1 and 152 (91.6%) and 14 (8.4%) in group 2. <h3>Conclusions</h3> The IL-1Ra allele I is associated with a higher susceptibility to febrile convulsion, which may become a useful marker for predicting the development of febrile convulsions. The IL-1β exon 5 gene polymorphisms are not a useful marker for predicting the susceptibility to febrile convulsions." @default.
• W2159683398 created "2016-06-24" @default.
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• W2159683398 date "2002-06-01" @default.
• W2159683398 modified "2023-09-25" @default.
• W2159683398 title "Polymorphisms for Interleukin 1β Exon 5 and Interleukin 1 Receptor Antagonist in Taiwanese Children With Febrile Convulsions" @default.
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• W2159683398 doi "https://doi.org/10.1001/archpedi.156.6.545" @default.
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