Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159704995> ?p ?o ?g. }
- W2159704995 endingPage "496" @default.
- W2159704995 startingPage "481" @default.
- W2159704995 abstract "Medullary thyroid carcinoma (MTC) is responsible for 13.4% of the total deaths attributable to thyroid cancer in human beings and research on MTC over the last 40 years has identified the RET proto-oncogene as a very relevant component of development of both sporadic and hereditary MTC. An activating germline RET proto-oncogene mutation responsible for a multiple endocrine neoplasia syndrome type 2 (MEN2) or a familial hereditary MTC syndrome is carried by 25% to 35% of patients with MTC. The recognition of RET proto-oncogene mutations by genetic sequencing has allowed us to differentiate hereditary from sporadic MTC, so that it is now possible to identify and treat children at risk for this disease before development of metastasis. Thanks to this discovery, we can now establish the association of MTC with other tumors in the context of MEN2 syndrome; determine adequate follow-up, prognosis, and treatment for patients with hereditary disease; and use this information to develop new therapies against both sporadic and hereditary MTCs." @default.
- W2159704995 created "2016-06-24" @default.
- W2159704995 creator A5037920180 @default.
- W2159704995 creator A5046671975 @default.
- W2159704995 creator A5084109000 @default.
- W2159704995 date "2008-06-01" @default.
- W2159704995 modified "2023-10-17" @default.
- W2159704995 title "Management of Medullary Thyroid Carcinoma" @default.
- W2159704995 cites W1966406203 @default.
- W2159704995 cites W1967980350 @default.
- W2159704995 cites W1970508146 @default.
- W2159704995 cites W1973291039 @default.
- W2159704995 cites W1977133363 @default.
- W2159704995 cites W1977464433 @default.
- W2159704995 cites W1987606251 @default.
- W2159704995 cites W1996179912 @default.
- W2159704995 cites W2012141473 @default.
- W2159704995 cites W2031301095 @default.
- W2159704995 cites W2031725781 @default.
- W2159704995 cites W2032385954 @default.
- W2159704995 cites W2034721431 @default.
- W2159704995 cites W2038349854 @default.
- W2159704995 cites W2041065101 @default.
- W2159704995 cites W2043569734 @default.
- W2159704995 cites W2044761914 @default.
- W2159704995 cites W2047279722 @default.
- W2159704995 cites W2053057607 @default.
- W2159704995 cites W2053731338 @default.
- W2159704995 cites W2063861052 @default.
- W2159704995 cites W2065432648 @default.
- W2159704995 cites W2068005285 @default.
- W2159704995 cites W207587488 @default.
- W2159704995 cites W2078610780 @default.
- W2159704995 cites W2082260444 @default.
- W2159704995 cites W2084191984 @default.
- W2159704995 cites W2092228137 @default.
- W2159704995 cites W2097029502 @default.
- W2159704995 cites W2099257302 @default.
- W2159704995 cites W2101151768 @default.
- W2159704995 cites W2111744166 @default.
- W2159704995 cites W2127014678 @default.
- W2159704995 cites W2129276274 @default.
- W2159704995 cites W2139200459 @default.
- W2159704995 cites W2139248078 @default.
- W2159704995 cites W2147675530 @default.
- W2159704995 cites W2147994473 @default.
- W2159704995 cites W2158510116 @default.
- W2159704995 cites W2158730241 @default.
- W2159704995 cites W2160028332 @default.
- W2159704995 cites W2160863198 @default.
- W2159704995 cites W2162807391 @default.
- W2159704995 cites W2277971486 @default.
- W2159704995 cites W2312226973 @default.
- W2159704995 cites W2316520927 @default.
- W2159704995 cites W2317654902 @default.
- W2159704995 cites W2323135776 @default.
- W2159704995 cites W2340837163 @default.
- W2159704995 cites W2967049309 @default.
- W2159704995 cites W4229498739 @default.
- W2159704995 cites W4232812360 @default.
- W2159704995 cites W4233607091 @default.
- W2159704995 cites W4237956739 @default.
- W2159704995 cites W4238127843 @default.
- W2159704995 cites W4241623643 @default.
- W2159704995 cites W4245232102 @default.
- W2159704995 cites W4245859029 @default.
- W2159704995 cites W4246313933 @default.
- W2159704995 cites W4248988283 @default.
- W2159704995 cites W4254125035 @default.
- W2159704995 cites W4295768330 @default.
- W2159704995 cites W4299332003 @default.
- W2159704995 doi "https://doi.org/10.1016/j.ecl.2008.03.001" @default.
- W2159704995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18502338" @default.
- W2159704995 hasPublicationYear "2008" @default.
- W2159704995 type Work @default.
- W2159704995 sameAs 2159704995 @default.
- W2159704995 citedByCount "76" @default.
- W2159704995 countsByYear W21597049952012 @default.
- W2159704995 countsByYear W21597049952013 @default.
- W2159704995 countsByYear W21597049952014 @default.
- W2159704995 countsByYear W21597049952015 @default.
- W2159704995 countsByYear W21597049952016 @default.
- W2159704995 countsByYear W21597049952017 @default.
- W2159704995 countsByYear W21597049952019 @default.
- W2159704995 countsByYear W21597049952020 @default.
- W2159704995 countsByYear W21597049952021 @default.
- W2159704995 countsByYear W21597049952022 @default.
- W2159704995 countsByYear W21597049952023 @default.
- W2159704995 crossrefType "journal-article" @default.
- W2159704995 hasAuthorship W2159704995A5037920180 @default.
- W2159704995 hasAuthorship W2159704995A5046671975 @default.
- W2159704995 hasAuthorship W2159704995A5084109000 @default.
- W2159704995 hasConcept C104317684 @default.
- W2159704995 hasConcept C109825262 @default.
- W2159704995 hasConcept C126322002 @default.
- W2159704995 hasConcept C13514818 @default.
- W2159704995 hasConcept C142724271 @default.
- W2159704995 hasConcept C143998085 @default.