FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159718837> ?p ?o ?g. }

• W2159718837 endingPage "3830" @default.
• W2159718837 startingPage "3822" @default.
• W2159718837 abstract "Development of neural circuitry depends on the integration of signaling pathways to coordinate specification, proliferation and differentiation of cell types in the right number, in the right place, at the right time. Zinc finger protein 423 (Zfp423), a 30-zinc finger transcription factor, forms alternate complexes with components of several developmental signaling pathways, suggesting it as a point of signal integration during brain development. We previously showed that mice lacking Zfp423 have reduced proliferation of cerebellar precursor cells, resulting in complete loss of vermis and variable hypoplasia of cerebellar hemispheres. Here, we show that Zfp423−/− hemisphere malformations are shaped by both genetic and non-genetic factors, producing distinct phenotype distributions in different inbred genetic backgrounds. In genetic mapping studies, we identify four additive modifier loci (Amzn1–4) and seven synthetically interacting loci (Smzn1.1–3.1) that together explain approximately one-third of the phenotypic variance. Strain-specific sequence polymorphism and expression data provide a reduced list of functional variant candidate genes at each modifier locus. Environmental covariates add only modest explanatory power, suggesting an additional stochastic component. These results provide a comprehensive analysis of sources of phenotype variation in a model of hindbrain malformation." @default.
• W2159718837 created "2016-06-24" @default.
• W2159718837 creator A5034799294 @default.
• W2159718837 creator A5040786852 @default.
• W2159718837 creator A5046522509 @default.
• W2159718837 creator A5052458358 @default.
• W2159718837 creator A5059554334 @default.
• W2159718837 creator A5066070531 @default.
• W2159718837 creator A5084324248 @default.
• W2159718837 date "2011-07-05" @default.
• W2159718837 modified "2023-10-03" @default.
• W2159718837 title "Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice" @default.
• W2159718837 cites W1497281854 @default.
• W2159718837 cites W1534997736 @default.
• W2159718837 cites W1845077221 @default.
• W2159718837 cites W1967290608 @default.
• W2159718837 cites W1968251266 @default.
• W2159718837 cites W1975919464 @default.
• W2159718837 cites W1976741643 @default.
• W2159718837 cites W1981492377 @default.
• W2159718837 cites W1986595328 @default.
• W2159718837 cites W1991204443 @default.
• W2159718837 cites W1991915230 @default.
• W2159718837 cites W2001142544 @default.
• W2159718837 cites W2001170778 @default.
• W2159718837 cites W2001862736 @default.
• W2159718837 cites W2008787085 @default.
• W2159718837 cites W2011455759 @default.
• W2159718837 cites W2018000293 @default.
• W2159718837 cites W2024974717 @default.
• W2159718837 cites W2037700340 @default.
• W2159718837 cites W2042155385 @default.
• W2159718837 cites W2042657989 @default.
• W2159718837 cites W2047964648 @default.
• W2159718837 cites W2055046556 @default.
• W2159718837 cites W2060983457 @default.
• W2159718837 cites W2064462911 @default.
• W2159718837 cites W2069147696 @default.
• W2159718837 cites W2074814691 @default.
• W2159718837 cites W2078701218 @default.
• W2159718837 cites W2086302637 @default.
• W2159718837 cites W2107189114 @default.
• W2159718837 cites W2113764519 @default.
• W2159718837 cites W2116053845 @default.
• W2159718837 cites W2122160273 @default.
• W2159718837 cites W2124070731 @default.
• W2159718837 cites W2139931214 @default.
• W2159718837 cites W2142361468 @default.
• W2159718837 cites W2143175476 @default.
• W2159718837 cites W2148405434 @default.
• W2159718837 cites W2149945426 @default.
• W2159718837 cites W2160882954 @default.
• W2159718837 cites W2166080631 @default.
• W2159718837 cites W2171816499 @default.
• W2159718837 cites W4230914450 @default.
• W2159718837 doi "https://doi.org/10.1093/hmg/ddr300" @default.
• W2159718837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3168291" @default.
• W2159718837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21729880" @default.
• W2159718837 hasPublicationYear "2011" @default.
• W2159718837 type Work @default.
• W2159718837 sameAs 2159718837 @default.
• W2159718837 citedByCount "16" @default.
• W2159718837 countsByYear W21597188372012 @default.
• W2159718837 countsByYear W21597188372013 @default.
• W2159718837 countsByYear W21597188372014 @default.
• W2159718837 countsByYear W21597188372015 @default.
• W2159718837 countsByYear W21597188372016 @default.
• W2159718837 countsByYear W21597188372017 @default.
• W2159718837 countsByYear W21597188372018 @default.
• W2159718837 countsByYear W21597188372020 @default.
• W2159718837 crossrefType "journal-article" @default.
• W2159718837 hasAuthorship W2159718837A5034799294 @default.
• W2159718837 hasAuthorship W2159718837A5040786852 @default.
• W2159718837 hasAuthorship W2159718837A5046522509 @default.
• W2159718837 hasAuthorship W2159718837A5052458358 @default.
• W2159718837 hasAuthorship W2159718837A5059554334 @default.
• W2159718837 hasAuthorship W2159718837A5066070531 @default.
• W2159718837 hasAuthorship W2159718837A5084324248 @default.
• W2159718837 hasBestOaLocation W21597188371 @default.
• W2159718837 hasConcept C104317684 @default.
• W2159718837 hasConcept C127716648 @default.
• W2159718837 hasConcept C24284526 @default.
• W2159718837 hasConcept C2777075493 @default.
• W2159718837 hasConcept C2777124376 @default.
• W2159718837 hasConcept C54355233 @default.
• W2159718837 hasConcept C68873052 @default.
• W2159718837 hasConcept C84597430 @default.
• W2159718837 hasConcept C86339819 @default.
• W2159718837 hasConcept C86803240 @default.
• W2159718837 hasConceptScore W2159718837C104317684 @default.
• W2159718837 hasConceptScore W2159718837C127716648 @default.
• W2159718837 hasConceptScore W2159718837C24284526 @default.
• W2159718837 hasConceptScore W2159718837C2777075493 @default.
• W2159718837 hasConceptScore W2159718837C2777124376 @default.
• W2159718837 hasConceptScore W2159718837C54355233 @default.
• W2159718837 hasConceptScore W2159718837C68873052 @default.
• W2159718837 hasConceptScore W2159718837C84597430 @default.
• W2159718837 hasConceptScore W2159718837C86339819 @default.

• next