FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159722072> ?p ?o ?g. }

• W2159722072 endingPage "262" @default.
• W2159722072 startingPage "254" @default.
• W2159722072 abstract "Safety analysis to estimate the effect of a treatment on an adverse event poses a challenging statistical problem even in randomized controlled trials because these events are typically rare, so studies originally powered for efficacy are underpowered for safety outcomes. A meta-analysis of data pooled across multiple studies may increase power, but missingness in the outcome or failed randomization can introduce bias. This article illustrates how targeted maximum likelihood estimation (TMLE) can be applied in a meta-analysis to reduce bias in causal effect estimates, and compares performance with other estimators in the literature. A simulation study in which missingness in the outcome is at random or completely at random highlights the differences in estimators with respect to the potential gains in bias and efficiency. Risk difference, relative risk, and odds ratio of the effect of treatment on 30-day mortality are estimated from data from eight randomized controlled trials. When an outcome event is rare there may be little opportunity to improve efficiency, and associations between covariates and the outcome may be hard to detect. TMLE attempts to exploit the available information to either meet or exceed the performance of a less sophisticated estimator." @default.
• W2159722072 created "2016-06-24" @default.
• W2159722072 creator A5048956065 @default.
• W2159722072 creator A5055204699 @default.
• W2159722072 date "2013-02-04" @default.
• W2159722072 modified "2023-09-27" @default.
• W2159722072 title "An Application of Targeted Maximum Likelihood Estimation to the Meta-Analysis of Safety Data" @default.
• W2159722072 cites W128574488 @default.
• W2159722072 cites W1513618424 @default.
• W2159722072 cites W1572302037 @default.
• W2159722072 cites W1622753297 @default.
• W2159722072 cites W1989898472 @default.
• W2159722072 cites W1990139173 @default.
• W2159722072 cites W1999188374 @default.
• W2159722072 cites W2008557562 @default.
• W2159722072 cites W2018331991 @default.
• W2159722072 cites W2022450888 @default.
• W2159722072 cites W2032038468 @default.
• W2159722072 cites W2050127204 @default.
• W2159722072 cites W2070030011 @default.
• W2159722072 cites W2082299845 @default.
• W2159722072 cites W2095512807 @default.
• W2159722072 cites W2117845059 @default.
• W2159722072 cites W2137370054 @default.
• W2159722072 cites W2148429341 @default.
• W2159722072 cites W2331324207 @default.
• W2159722072 cites W3105930661 @default.
• W2159722072 cites W3122781290 @default.
• W2159722072 cites W4233056867 @default.
• W2159722072 cites W4248240383 @default.
• W2159722072 doi "https://doi.org/10.1111/j.1541-0420.2012.01829.x" @default.
• W2159722072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23379761" @default.
• W2159722072 hasPublicationYear "2013" @default.
• W2159722072 type Work @default.
• W2159722072 sameAs 2159722072 @default.
• W2159722072 citedByCount "10" @default.
• W2159722072 countsByYear W21597220722013 @default.
• W2159722072 countsByYear W21597220722015 @default.
• W2159722072 countsByYear W21597220722016 @default.
• W2159722072 countsByYear W21597220722022 @default.
• W2159722072 countsByYear W21597220722023 @default.
• W2159722072 crossrefType "journal-article" @default.
• W2159722072 hasAuthorship W2159722072A5048956065 @default.
• W2159722072 hasAuthorship W2159722072A5055204699 @default.
• W2159722072 hasConcept C105795698 @default.
• W2159722072 hasConcept C119043178 @default.
• W2159722072 hasConcept C121332964 @default.
• W2159722072 hasConcept C126322002 @default.
• W2159722072 hasConcept C144237770 @default.
• W2159722072 hasConcept C148220186 @default.
• W2159722072 hasConcept C149782125 @default.
• W2159722072 hasConcept C168563851 @default.
• W2159722072 hasConcept C168743327 @default.
• W2159722072 hasConcept C185429906 @default.
• W2159722072 hasConcept C2777317252 @default.
• W2159722072 hasConcept C2779662365 @default.
• W2159722072 hasConcept C33923547 @default.
• W2159722072 hasConcept C41008148 @default.
• W2159722072 hasConcept C62520636 @default.
• W2159722072 hasConcept C71924100 @default.
• W2159722072 hasConcept C9357733 @default.
• W2159722072 hasConcept C95190672 @default.
• W2159722072 hasConcept C96608239 @default.
• W2159722072 hasConceptScore W2159722072C105795698 @default.
• W2159722072 hasConceptScore W2159722072C119043178 @default.
• W2159722072 hasConceptScore W2159722072C121332964 @default.
• W2159722072 hasConceptScore W2159722072C126322002 @default.
• W2159722072 hasConceptScore W2159722072C144237770 @default.
• W2159722072 hasConceptScore W2159722072C148220186 @default.
• W2159722072 hasConceptScore W2159722072C149782125 @default.
• W2159722072 hasConceptScore W2159722072C168563851 @default.
• W2159722072 hasConceptScore W2159722072C168743327 @default.
• W2159722072 hasConceptScore W2159722072C185429906 @default.
• W2159722072 hasConceptScore W2159722072C2777317252 @default.
• W2159722072 hasConceptScore W2159722072C2779662365 @default.
• W2159722072 hasConceptScore W2159722072C33923547 @default.
• W2159722072 hasConceptScore W2159722072C41008148 @default.
• W2159722072 hasConceptScore W2159722072C62520636 @default.
• W2159722072 hasConceptScore W2159722072C71924100 @default.
• W2159722072 hasConceptScore W2159722072C9357733 @default.
• W2159722072 hasConceptScore W2159722072C95190672 @default.
• W2159722072 hasConceptScore W2159722072C96608239 @default.
• W2159722072 hasIssue "1" @default.
• W2159722072 hasLocation W21597220721 @default.
• W2159722072 hasLocation W21597220722 @default.
• W2159722072 hasOpenAccess W2159722072 @default.
• W2159722072 hasPrimaryLocation W21597220721 @default.
• W2159722072 hasRelatedWork W1856727413 @default.
• W2159722072 hasRelatedWork W2026599052 @default.
• W2159722072 hasRelatedWork W2030502605 @default.
• W2159722072 hasRelatedWork W2038710811 @default.
• W2159722072 hasRelatedWork W2121754044 @default.
• W2159722072 hasRelatedWork W2130397726 @default.
• W2159722072 hasRelatedWork W2147234629 @default.
• W2159722072 hasRelatedWork W2885634977 @default.
• W2159722072 hasRelatedWork W2913462076 @default.
• W2159722072 hasRelatedWork W4362602876 @default.
• W2159722072 hasVolume "69" @default.

• next