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- W2159729227 abstract "We thank Dr. Chamberlain and Drs. Wick and Weller for their careful evaluation of our publication1 and their thoughtful comments. We would like to take the opportunity to respond to their comments to this randomized and controlled phase IIb trabedersen study.Traditionally, drug development in oncology has been based on single-arm historically controlled phase II studies. To avoid the pitfalls associated with a single-arm design for phase II studies, randomization and a prospective control arm have been recommended to generate hypotheses that are to be confirmed in subsequent phase III studies.2,3We therefore designed the trabedersen study in high-grade glioma as a randomized and active-controlled phase IIb study with high-quality standards, including central histopathology and central MRI reading." @default.
- W2159729227 created "2016-06-24" @default.
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- W2159729227 date "2011-05-01" @default.
- W2159729227 modified "2023-09-27" @default.
- W2159729227 title "Response to MC Chamberlain: Convection-enhanced delivery of transforming growth factor- 2 inhibitor trabedersen for recurrent high-grade gliomas: efficacy real or imagined?, in reference to W Wick and M Weller: Trabedersen to target transforming growth factor- : when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142)" @default.
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- W2159729227 doi "https://doi.org/10.1093/neuonc/nor047" @default.
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