FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159737650> ?p ?o ?g. }

• W2159737650 abstract "Summary. Chronic hepatitis C virus (HCV) infection is associated with chronic inflammation of liver, which leads to the development of cirrhosis and hepatocellular carcinoma (HCC). Because of severe side effects and only a 50–70% cure rate in genotype 1 HCV‐infected patients upon current standard treatment with pegylated interferon‐α plus ribavirin, new therapeutic regimens are still needed. San‐Huang‐Xie‐Xin‐Tang (SHXT) is a transitional Chinese herbal formula, composed of Rhei rhizoma , Scutellaria radix and Coptidis rhizome , and possesses anti‐inflammatory effect. Here, we describe a (+)‐catechin‐containing fraction extracted from SHXT, referred as SHXT‐frC, exhibited effective inhibition of HCV replication, with selectivity index value (SI; CC 50 /EC 50 ) of 84, and displayed synergistic anti‐HCV effects when combined with interferon‐α, HCV protease inhibitor telaprevir or polymerase inhibitor 2′‐ C ‐methylcytidine. The activation of factor‐κB (NF‐κB) and cyclooxygenase‐2 (COX‐2) signalling pathway has particular relevance to HCV‐associated HCC. SHXT‐frC treatment also caused a concentration‐dependent decrease in the induction of COX‐2 and NF‐κB expression caused by either HCV replication or HCV NS5A protein. Collectively, SHXT‐frC could be an adjuvant treatment for patients with HCV‐induced liver diseases." @default.
• W2159737650 created "2016-06-24" @default.
• W2159737650 creator A5008645903 @default.
• W2159737650 creator A5024396869 @default.
• W2159737650 creator A5051674327 @default.
• W2159737650 creator A5052252531 @default.
• W2159737650 creator A5066399911 @default.
• W2159737650 creator A5086532638 @default.
• W2159737650 date "2011-01-20" @default.
• W2159737650 modified "2023-10-13" @default.
• W2159737650 title "San‐Huang‐Xie‐Xin‐Tang extract suppresses hepatitis C virus replication and virus‐induced cyclooxygenase‐2 expression" @default.
• W2159737650 cites W1964730884 @default.
• W2159737650 cites W1969985837 @default.
• W2159737650 cites W1972116068 @default.
• W2159737650 cites W1987630665 @default.
• W2159737650 cites W1990057587 @default.
• W2159737650 cites W1991378085 @default.
• W2159737650 cites W1991576415 @default.
• W2159737650 cites W1997998321 @default.
• W2159737650 cites W1998687750 @default.
• W2159737650 cites W2003579943 @default.
• W2159737650 cites W2004385874 @default.
• W2159737650 cites W2006120055 @default.
• W2159737650 cites W2010156396 @default.
• W2159737650 cites W2012715321 @default.
• W2159737650 cites W2015216410 @default.
• W2159737650 cites W2018264085 @default.
• W2159737650 cites W2022394822 @default.
• W2159737650 cites W2025866553 @default.
• W2159737650 cites W2029425023 @default.
• W2159737650 cites W2031748750 @default.
• W2159737650 cites W2033842971 @default.
• W2159737650 cites W2036915718 @default.
• W2159737650 cites W2048490393 @default.
• W2159737650 cites W2049052313 @default.
• W2159737650 cites W2059395217 @default.
• W2159737650 cites W2059831490 @default.
• W2159737650 cites W2060483294 @default.
• W2159737650 cites W2061782770 @default.
• W2159737650 cites W2064841496 @default.
• W2159737650 cites W2077183006 @default.
• W2159737650 cites W2077945404 @default.
• W2159737650 cites W2078887917 @default.
• W2159737650 cites W2085297322 @default.
• W2159737650 cites W2086726747 @default.
• W2159737650 cites W2088185132 @default.
• W2159737650 cites W2092871597 @default.
• W2159737650 cites W2093271104 @default.
• W2159737650 cites W2105574411 @default.
• W2159737650 cites W2111736586 @default.
• W2159737650 cites W2117745318 @default.
• W2159737650 cites W2125701478 @default.
• W2159737650 cites W2127362097 @default.
• W2159737650 cites W2140369033 @default.
• W2159737650 cites W2159156852 @default.
• W2159737650 cites W2162384376 @default.
• W2159737650 cites W2166189758 @default.
• W2159737650 doi "https://doi.org/10.1111/j.1365-2893.2010.01424.x" @default.
• W2159737650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7185454" @default.
• W2159737650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21692943" @default.
• W2159737650 hasPublicationYear "2011" @default.
• W2159737650 type Work @default.
• W2159737650 sameAs 2159737650 @default.
• W2159737650 citedByCount "30" @default.
• W2159737650 countsByYear W21597376502012 @default.
• W2159737650 countsByYear W21597376502013 @default.
• W2159737650 countsByYear W21597376502014 @default.
• W2159737650 countsByYear W21597376502015 @default.
• W2159737650 countsByYear W21597376502016 @default.
• W2159737650 countsByYear W21597376502017 @default.
• W2159737650 countsByYear W21597376502018 @default.
• W2159737650 countsByYear W21597376502020 @default.
• W2159737650 countsByYear W21597376502021 @default.
• W2159737650 countsByYear W21597376502023 @default.
• W2159737650 crossrefType "journal-article" @default.
• W2159737650 hasAuthorship W2159737650A5008645903 @default.
• W2159737650 hasAuthorship W2159737650A5024396869 @default.
• W2159737650 hasAuthorship W2159737650A5051674327 @default.
• W2159737650 hasAuthorship W2159737650A5052252531 @default.
• W2159737650 hasAuthorship W2159737650A5066399911 @default.
• W2159737650 hasAuthorship W2159737650A5086532638 @default.
• W2159737650 hasBestOaLocation W21597376501 @default.
• W2159737650 hasConcept C126322002 @default.
• W2159737650 hasConcept C159047783 @default.
• W2159737650 hasConcept C203014093 @default.
• W2159737650 hasConcept C2522874641 @default.
• W2159737650 hasConcept C2776178377 @default.
• W2159737650 hasConcept C2776408679 @default.
• W2159737650 hasConcept C2776461080 @default.
• W2159737650 hasConcept C2777103181 @default.
• W2159737650 hasConcept C2777159539 @default.
• W2159737650 hasConcept C2777214474 @default.
• W2159737650 hasConcept C2777863537 @default.
• W2159737650 hasConcept C2778019345 @default.
• W2159737650 hasConcept C2778159067 @default.
• W2159737650 hasConcept C2780040827 @default.
• W2159737650 hasConcept C2781463415 @default.
• W2159737650 hasConcept C71924100 @default.
• W2159737650 hasConcept C98274493 @default.
• W2159737650 hasConceptScore W2159737650C126322002 @default.

• next