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• W2159755514 abstract "Excessive concentrations of L-glutamate (glutamate) have been found to posses neurotoxic properties. This study investigates how stress induced by strong physical exercise effects blood glutamate, 2-ketoglutarate, Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) levels. The relationship between muscle damage caused by strong physical exercise and blood glutamate levels was also examined. Twenty-two healthy volunteers engaged in intense veloergometry (spinning) for a duration of 60 minutes. Two 10 minute peaks of extremely intense exercise were performed at 10 minutes and 50 minutes after the start of exercise. After 60 minutes of exercise, volunteers were monitored for an additional 180 minutes in resting conditions. Blood samples for determination of glutamate and 2-ketoglutarate levels were collected prior to exercise and then every 30 min for entire experiment. Blood samples were also taken at those time points to measure glutamate, 2-ketoglutarate, AST, ALT, creatine phosphokinase (CPK), myoglobin, lactate and venous blood gas levels. Blood glutamate levels were significantly elevated throughout the exercise session (P less than 0.001) and then returned to baseline levels at the cessation of exercise. 2-ketoglutarate, a product of glutamate metabolism, reached significantly elevated levels at 30 minutes (P less than 0.01) from the start of exercise and remained elevated up to 240 minutes post exercise initiation (P less than 0.001). AST and ALT levels were elevated at 60 minutes when compared to baseline. AST levels remained elevated at 240 minutes, unlike ALT levels which returned to baseline values at 240 minutes. Strong physical exercise leads to a significant elevation in blood glutamate, most likely as a result of skeletal muscle damage. 2-ketoglutarate was also found to be elevated for long periods of time, reflecting an ongoing process of glutamate breakdown. Elevated concentrations of AST and ALT in plasma reflect the importance of these enzymes in the maintenance of stable blood glutamate concentrations." @default.
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• W2159755514 date "2012-01-01" @default.
• W2159755514 modified "2023-09-23" @default.
• W2159755514 title "Effects of strong physical exercise on blood glutamate and its metabolite 2-ketoglutarate levels in healthy volunteers." @default.
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• W2159755514 cites W1845908988 @default.
• W2159755514 cites W1964535311 @default.
• W2159755514 cites W1967174704 @default.
• W2159755514 cites W1973653575 @default.
• W2159755514 cites W1974368862 @default.
• W2159755514 cites W1978137556 @default.
• W2159755514 cites W1981606780 @default.
• W2159755514 cites W1984334766 @default.
• W2159755514 cites W1985781221 @default.
• W2159755514 cites W1990064268 @default.
• W2159755514 cites W1991801669 @default.
• W2159755514 cites W1993331896 @default.
• W2159755514 cites W1993372850 @default.
• W2159755514 cites W2002261163 @default.
• W2159755514 cites W2003068392 @default.
• W2159755514 cites W2008418681 @default.
• W2159755514 cites W2009025414 @default.
• W2159755514 cites W2010147536 @default.
• W2159755514 cites W2018588185 @default.
• W2159755514 cites W2024132052 @default.
• W2159755514 cites W2025005051 @default.
• W2159755514 cites W2026022416 @default.
• W2159755514 cites W2029379167 @default.
• W2159755514 cites W2038317423 @default.
• W2159755514 cites W2039916841 @default.
• W2159755514 cites W2042791920 @default.
• W2159755514 cites W2047804085 @default.
• W2159755514 cites W2048841941 @default.
• W2159755514 cites W2051662544 @default.
• W2159755514 cites W2059149137 @default.
• W2159755514 cites W2059805141 @default.
• W2159755514 cites W2064443971 @default.
• W2159755514 cites W2065969029 @default.
• W2159755514 cites W2066191550 @default.
• W2159755514 cites W2067106012 @default.
• W2159755514 cites W2072494956 @default.
• W2159755514 cites W2073595496 @default.
• W2159755514 cites W2078517229 @default.
• W2159755514 cites W2092658609 @default.
• W2159755514 cites W2099867701 @default.
• W2159755514 cites W2104792456 @default.
• W2159755514 cites W2104873390 @default.
• W2159755514 cites W2106731245 @default.
• W2159755514 cites W2110634350 @default.
• W2159755514 cites W2130190854 @default.
• W2159755514 cites W2137491003 @default.
• W2159755514 cites W2140269135 @default.
• W2159755514 cites W2147691942 @default.
• W2159755514 cites W2148980073 @default.
• W2159755514 cites W2153899201 @default.
• W2159755514 cites W2162616806 @default.
• W2159755514 cites W2164254780 @default.
• W2159755514 cites W2167974925 @default.
• W2159755514 cites W2180338234 @default.
• W2159755514 cites W2315276202 @default.
• W2159755514 cites W2399526827 @default.
• W2159755514 cites W2409288187 @default.
• W2159755514 cites W2413472216 @default.
• W2159755514 cites W2469554725 @default.
• W2159755514 cites W249325067 @default.
• W2159755514 cites W67770790 @default.
• W2159755514 cites W74801939 @default.
• W2159755514 cites W2013176208 @default.
• W2159755514 cites W211292984 @default.
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• W2159755514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23377269" @default.
• W2159755514 hasPublicationYear "2012" @default.
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