Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159766146> ?p ?o ?g. }
- W2159766146 endingPage "768" @default.
- W2159766146 startingPage "759" @default.
- W2159766146 abstract "The concept of local renin-angiotensin systems has been introduced almost 20 years ago to explain the beneficial blood pressure-independent effects of ACE inhibitors and AT(1) receptor antagonists in cardiovascular diseases. In the past decade, research has focussed on the local effects of angiotensin II rather than on the mechanism(s) of its local generation. This review addresses several of the unanswered questions with regard to tissue angiotensin II generation, focussing in particular on the heart and vascular wall: (1) what is the origin of the renin that is required to generate angiotensin II locally, (2) where does tissue angiotensin generation occur (intra- versus extracellular), (3) what is the importance of alternative (non-renin, non-ACE) angiotensin-generating enzymes, (4) do ACE inhibitors and AT(1) receptor antagonists exert local effects that are renin-angiotensin system independent (thereby incorrectly leading to the conclusion that they interfere with the local generation or effects of angiotensin II), and (5) to what degree do differences in tissue angiotensin generation underlie the association between cardiovascular diseases and renin-angiotensin system gene polymorphisms?" @default.
- W2159766146 created "2016-06-24" @default.
- W2159766146 creator A5046295598 @default.
- W2159766146 date "2003-06-01" @default.
- W2159766146 modified "2023-09-23" @default.
- W2159766146 title "Local renin–angiotensin systems: the unanswered questions" @default.
- W2159766146 cites W1495026747 @default.
- W2159766146 cites W1513202942 @default.
- W2159766146 cites W1825846573 @default.
- W2159766146 cites W1843891181 @default.
- W2159766146 cites W1970672721 @default.
- W2159766146 cites W1973485369 @default.
- W2159766146 cites W1975067849 @default.
- W2159766146 cites W1976226569 @default.
- W2159766146 cites W1980771632 @default.
- W2159766146 cites W1983251645 @default.
- W2159766146 cites W1984346054 @default.
- W2159766146 cites W1986049576 @default.
- W2159766146 cites W1994547804 @default.
- W2159766146 cites W2006999079 @default.
- W2159766146 cites W2008082797 @default.
- W2159766146 cites W2010968412 @default.
- W2159766146 cites W2014575233 @default.
- W2159766146 cites W2025286686 @default.
- W2159766146 cites W2026885101 @default.
- W2159766146 cites W2028076671 @default.
- W2159766146 cites W2030836837 @default.
- W2159766146 cites W2037962635 @default.
- W2159766146 cites W2038508711 @default.
- W2159766146 cites W2039291325 @default.
- W2159766146 cites W2040097961 @default.
- W2159766146 cites W2047089949 @default.
- W2159766146 cites W2050542806 @default.
- W2159766146 cites W2050679214 @default.
- W2159766146 cites W2051172188 @default.
- W2159766146 cites W2051332153 @default.
- W2159766146 cites W2055838514 @default.
- W2159766146 cites W2057441702 @default.
- W2159766146 cites W2059878261 @default.
- W2159766146 cites W2068359901 @default.
- W2159766146 cites W2072116327 @default.
- W2159766146 cites W2075089300 @default.
- W2159766146 cites W2075228337 @default.
- W2159766146 cites W2076789061 @default.
- W2159766146 cites W2078172019 @default.
- W2159766146 cites W2080452768 @default.
- W2159766146 cites W2081088335 @default.
- W2159766146 cites W2083631932 @default.
- W2159766146 cites W2083898560 @default.
- W2159766146 cites W2086041680 @default.
- W2159766146 cites W2091566117 @default.
- W2159766146 cites W2093548319 @default.
- W2159766146 cites W2095317470 @default.
- W2159766146 cites W2097362788 @default.
- W2159766146 cites W2100278284 @default.
- W2159766146 cites W2101637012 @default.
- W2159766146 cites W2105991285 @default.
- W2159766146 cites W2106203113 @default.
- W2159766146 cites W2106310487 @default.
- W2159766146 cites W2106330489 @default.
- W2159766146 cites W2109052012 @default.
- W2159766146 cites W2114325953 @default.
- W2159766146 cites W2115624311 @default.
- W2159766146 cites W2118626367 @default.
- W2159766146 cites W2119786999 @default.
- W2159766146 cites W2122595087 @default.
- W2159766146 cites W2124579523 @default.
- W2159766146 cites W2130310565 @default.
- W2159766146 cites W2131476379 @default.
- W2159766146 cites W2134032718 @default.
- W2159766146 cites W2134804167 @default.
- W2159766146 cites W2135074047 @default.
- W2159766146 cites W2137246274 @default.
- W2159766146 cites W2138917179 @default.
- W2159766146 cites W2140984295 @default.
- W2159766146 cites W2145366887 @default.
- W2159766146 cites W2146867563 @default.
- W2159766146 cites W2149266174 @default.
- W2159766146 cites W2151598399 @default.
- W2159766146 cites W2153027424 @default.
- W2159766146 cites W2153952409 @default.
- W2159766146 cites W2154543592 @default.
- W2159766146 cites W2168800815 @default.
- W2159766146 cites W2171765843 @default.
- W2159766146 cites W2324103256 @default.
- W2159766146 cites W2324804902 @default.
- W2159766146 cites W2329715591 @default.
- W2159766146 cites W2340576086 @default.
- W2159766146 cites W4230635008 @default.
- W2159766146 cites W4252397535 @default.
- W2159766146 cites W4322701606 @default.
- W2159766146 doi "https://doi.org/10.1016/s1357-2725(02)00178-4" @default.
- W2159766146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12676161" @default.
- W2159766146 hasPublicationYear "2003" @default.
- W2159766146 type Work @default.
- W2159766146 sameAs 2159766146 @default.
- W2159766146 citedByCount "112" @default.
- W2159766146 countsByYear W21597661462012 @default.