FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159767547> ?p ?o ?g. }

• W2159767547 abstract "Recent studies have implicated the role of differential co-expression or correlation structure in gene expression data to help explain phenotypic differences. However, few attempts have been made to characterize the function of variants based on their role in regulating differential co-expression. Here we describe a statistical methodology that identifies pairs of transcripts that display differential correlation structure conditioned on genotypes of variants that regulate co-expression. Additionally, we present a user-friendly, computationally efficient tool, dcVar, that can be applied to expression quantitative trait loci (eQTL) or RNA-Seq datasets to infer differential co-expression variants (dcVars). We apply dcVar to the HapMap3 eQTL dataset and demonstrate the utility of this methodology at uncovering novel function of variants of interest with examples from a height genome-wide association and cancer drug resistance. We provide evidence that differential correlation structure is a valuable intermediate molecular phenotype for further characterizing the function of variants identified in GWAS and related studies." @default.
• W2159767547 created "2016-06-24" @default.
• W2159767547 creator A5040774618 @default.
• W2159767547 creator A5049579672 @default.
• W2159767547 creator A5054483679 @default.
• W2159767547 creator A5054495173 @default.
• W2159767547 date "2015-10-19" @default.
• W2159767547 modified "2023-09-29" @default.
• W2159767547 title "dcVar: a method for identifying common variants that modulate differential correlation structures in gene expression data" @default.
• W2159767547 cites W1536266371 @default.
• W2159767547 cites W1587440170 @default.
• W2159767547 cites W1965055200 @default.
• W2159767547 cites W1966267765 @default.
• W2159767547 cites W1972236801 @default.
• W2159767547 cites W1973370947 @default.
• W2159767547 cites W1975542710 @default.
• W2159767547 cites W2000859405 @default.
• W2159767547 cites W2001280003 @default.
• W2159767547 cites W2009170877 @default.
• W2159767547 cites W2024675721 @default.
• W2159767547 cites W2051616601 @default.
• W2159767547 cites W2052968292 @default.
• W2159767547 cites W2081937284 @default.
• W2159767547 cites W2099086736 @default.
• W2159767547 cites W2104724027 @default.
• W2159767547 cites W2107916366 @default.
• W2159767547 cites W2108390464 @default.
• W2159767547 cites W2119590375 @default.
• W2159767547 cites W2122889774 @default.
• W2159767547 cites W2124404375 @default.
• W2159767547 cites W2125926930 @default.
• W2159767547 cites W2127190573 @default.
• W2159767547 cites W2130767371 @default.
• W2159767547 cites W2136091734 @default.
• W2159767547 cites W2141820415 @default.
• W2159767547 cites W2143989746 @default.
• W2159767547 cites W2150862213 @default.
• W2159767547 cites W2161633633 @default.
• W2159767547 cites W2162946128 @default.
• W2159767547 cites W2410416673 @default.
• W2159767547 cites W2951214768 @default.
• W2159767547 doi "https://doi.org/10.3389/fgene.2015.00312" @default.
• W2159767547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4609883" @default.
• W2159767547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26539209" @default.
• W2159767547 hasPublicationYear "2015" @default.
• W2159767547 type Work @default.
• W2159767547 sameAs 2159767547 @default.
• W2159767547 citedByCount "5" @default.
• W2159767547 countsByYear W21597675472016 @default.
• W2159767547 countsByYear W21597675472019 @default.
• W2159767547 countsByYear W21597675472020 @default.
• W2159767547 crossrefType "journal-article" @default.
• W2159767547 hasAuthorship W2159767547A5040774618 @default.
• W2159767547 hasAuthorship W2159767547A5049579672 @default.
• W2159767547 hasAuthorship W2159767547A5054483679 @default.
• W2159767547 hasAuthorship W2159767547A5054495173 @default.
• W2159767547 hasBestOaLocation W21597675471 @default.
• W2159767547 hasConcept C104317684 @default.
• W2159767547 hasConcept C106208931 @default.
• W2159767547 hasConcept C117220453 @default.
• W2159767547 hasConcept C127413603 @default.
• W2159767547 hasConcept C127716648 @default.
• W2159767547 hasConcept C135763542 @default.
• W2159767547 hasConcept C14036430 @default.
• W2159767547 hasConcept C146978453 @default.
• W2159767547 hasConcept C150194340 @default.
• W2159767547 hasConcept C153209595 @default.
• W2159767547 hasConcept C168393362 @default.
• W2159767547 hasConcept C186413461 @default.
• W2159767547 hasConcept C2524010 @default.
• W2159767547 hasConcept C33923547 @default.
• W2159767547 hasConcept C54355233 @default.
• W2159767547 hasConcept C70721500 @default.
• W2159767547 hasConcept C86803240 @default.
• W2159767547 hasConcept C93226319 @default.
• W2159767547 hasConceptScore W2159767547C104317684 @default.
• W2159767547 hasConceptScore W2159767547C106208931 @default.
• W2159767547 hasConceptScore W2159767547C117220453 @default.
• W2159767547 hasConceptScore W2159767547C127413603 @default.
• W2159767547 hasConceptScore W2159767547C127716648 @default.
• W2159767547 hasConceptScore W2159767547C135763542 @default.
• W2159767547 hasConceptScore W2159767547C14036430 @default.
• W2159767547 hasConceptScore W2159767547C146978453 @default.
• W2159767547 hasConceptScore W2159767547C150194340 @default.
• W2159767547 hasConceptScore W2159767547C153209595 @default.
• W2159767547 hasConceptScore W2159767547C168393362 @default.
• W2159767547 hasConceptScore W2159767547C186413461 @default.
• W2159767547 hasConceptScore W2159767547C2524010 @default.
• W2159767547 hasConceptScore W2159767547C33923547 @default.
• W2159767547 hasConceptScore W2159767547C54355233 @default.
• W2159767547 hasConceptScore W2159767547C70721500 @default.
• W2159767547 hasConceptScore W2159767547C86803240 @default.
• W2159767547 hasConceptScore W2159767547C93226319 @default.
• W2159767547 hasLocation W21597675471 @default.
• W2159767547 hasLocation W21597675472 @default.
• W2159767547 hasLocation W21597675473 @default.
• W2159767547 hasLocation W21597675474 @default.
• W2159767547 hasLocation W21597675475 @default.
• W2159767547 hasOpenAccess W2159767547 @default.
• W2159767547 hasPrimaryLocation W21597675471 @default.

• next