Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159787579> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2159787579 endingPage "803" @default.
- W2159787579 startingPage "798" @default.
- W2159787579 abstract "Studies of live attenuated cytomegalovirus (CMV) vaccine have recently been initiated in man. The possibilities of latent infection and disease resulting from reactivation of vaccine virus are major concerns. Because markers for attenuation of tissue culture-passaged mouse CMV (MCMV) exist, studies of potential adverse effects of vaccination were initiated in mice. Plaque-purified MCMV was passed 12 times in cell culture (vaccine virus) and shown to be attenuated by virtue of loss of lethality and diminished replication in reticuloendothelial organs of normal mice. Although subcutaneous inoculation of 10(5) plaque-forming units of wild virus was lethal for mice immunosuppressed with antilymphocyte serum (18/18 died), vaccine MCMV killed only 3/18 (P < 0.05) and was thus shown to be highly attenuated even in immunosuppressed animals. 4 mo after subcutaneous inoculation of vaccine MCMV, no infectious virus was detectable in the tissues of normal C(3)H mice. However, immunosuppression with anti-lymphocyte serum and cortisone caused MCMV reactivation, dissemination, and wide-spread cytomegalic inclusion disease in 19 of 20 animals. Characterization of the reactivating virus recovered from salivary glands indicated that reversion to virulence had occurred. Thus, vaccine MCMV, although markedly attenuated initially, established latent infection, reactivated after immunosuppression, and reverted to virulence, at least in salivary gland tissue. These data from the murine model substantiate the need for careful surveillance and virologic study of patients given experimental CMV vaccine." @default.
- W2159787579 created "2016-06-24" @default.
- W2159787579 creator A5029835300 @default.
- W2159787579 date "1980-04-01" @default.
- W2159787579 modified "2023-10-12" @default.
- W2159787579 title "Adverse Effects of Cytomegalovirus Vaccination in Mice" @default.
- W2159787579 cites W1595952932 @default.
- W2159787579 cites W1660599893 @default.
- W2159787579 cites W1904578404 @default.
- W2159787579 cites W1963551393 @default.
- W2159787579 cites W1966239960 @default.
- W2159787579 cites W1971218693 @default.
- W2159787579 cites W1974676789 @default.
- W2159787579 cites W2018199693 @default.
- W2159787579 cites W2032092033 @default.
- W2159787579 cites W2066178760 @default.
- W2159787579 cites W2079647175 @default.
- W2159787579 cites W2080479114 @default.
- W2159787579 cites W2107747657 @default.
- W2159787579 cites W2126287681 @default.
- W2159787579 cites W2143907288 @default.
- W2159787579 cites W2150569689 @default.
- W2159787579 cites W2294323603 @default.
- W2159787579 cites W2320515801 @default.
- W2159787579 cites W2322102521 @default.
- W2159787579 cites W2324672947 @default.
- W2159787579 cites W2325184241 @default.
- W2159787579 cites W48780628 @default.
- W2159787579 doi "https://doi.org/10.1172/jci109730" @default.
- W2159787579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/434465" @default.
- W2159787579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6244333" @default.
- W2159787579 hasPublicationYear "1980" @default.
- W2159787579 type Work @default.
- W2159787579 sameAs 2159787579 @default.
- W2159787579 citedByCount "24" @default.
- W2159787579 countsByYear W21597875792014 @default.
- W2159787579 countsByYear W21597875792019 @default.
- W2159787579 crossrefType "journal-article" @default.
- W2159787579 hasAuthorship W2159787579A5029835300 @default.
- W2159787579 hasBestOaLocation W21597875791 @default.
- W2159787579 hasConcept C104317684 @default.
- W2159787579 hasConcept C159047783 @default.
- W2159787579 hasConcept C203014093 @default.
- W2159787579 hasConcept C22070199 @default.
- W2159787579 hasConcept C2522874641 @default.
- W2159787579 hasConcept C2780252810 @default.
- W2159787579 hasConcept C54602769 @default.
- W2159787579 hasConcept C55493867 @default.
- W2159787579 hasConcept C60987743 @default.
- W2159787579 hasConcept C86803240 @default.
- W2159787579 hasConceptScore W2159787579C104317684 @default.
- W2159787579 hasConceptScore W2159787579C159047783 @default.
- W2159787579 hasConceptScore W2159787579C203014093 @default.
- W2159787579 hasConceptScore W2159787579C22070199 @default.
- W2159787579 hasConceptScore W2159787579C2522874641 @default.
- W2159787579 hasConceptScore W2159787579C2780252810 @default.
- W2159787579 hasConceptScore W2159787579C54602769 @default.
- W2159787579 hasConceptScore W2159787579C55493867 @default.
- W2159787579 hasConceptScore W2159787579C60987743 @default.
- W2159787579 hasConceptScore W2159787579C86803240 @default.
- W2159787579 hasIssue "4" @default.
- W2159787579 hasLocation W21597875791 @default.
- W2159787579 hasLocation W21597875792 @default.
- W2159787579 hasLocation W21597875793 @default.
- W2159787579 hasLocation W21597875794 @default.
- W2159787579 hasLocation W21597875795 @default.
- W2159787579 hasOpenAccess W2159787579 @default.
- W2159787579 hasPrimaryLocation W21597875791 @default.
- W2159787579 hasRelatedWork W1980070355 @default.
- W2159787579 hasRelatedWork W2022198341 @default.
- W2159787579 hasRelatedWork W2035643332 @default.
- W2159787579 hasRelatedWork W2053489723 @default.
- W2159787579 hasRelatedWork W2061872883 @default.
- W2159787579 hasRelatedWork W2083406763 @default.
- W2159787579 hasRelatedWork W2086778880 @default.
- W2159787579 hasRelatedWork W2159527899 @default.
- W2159787579 hasRelatedWork W3030634446 @default.
- W2159787579 hasRelatedWork W3045355607 @default.
- W2159787579 hasVolume "65" @default.
- W2159787579 isParatext "false" @default.
- W2159787579 isRetracted "false" @default.
- W2159787579 magId "2159787579" @default.
- W2159787579 workType "article" @default.