FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159794252> ?p ?o ?g. }

• W2159794252 endingPage "8190" @default.
• W2159794252 startingPage "8183" @default.
• W2159794252 abstract "ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G 2 /M transition and subsequently apoptosis. Here we examined the potential involvement of Wee-1 in Vpr-induced G 2 arrest. Wee-1 is a cellular protein kinase that inhibits Cdc2 activity, thereby preventing cells from proceeding through mitosis. We previously showed that the levels of Wee-1 correlate with Vpr-mediated apoptosis. Here, we demonstrate that Vpr-induced G 2 arrest correlated with delayed degradation of Wee-1 at G 2 /M. Experimental depletion of Wee-1 by a small interfering RNA directed to wee-1 mRNA alleviated Vpr-induced G 2 arrest and allowed apparently normal progression through M into G 1 . Similar results were observed when cells were arrested at G 2 following gamma irradiation. Thus, Wee-1 is integrally involved as a key cellular regulatory protein in the signal transduction pathway for HIV-1 Vpr-induced cell cycle arrest." @default.
• W2159794252 created "2016-06-24" @default.
• W2159794252 creator A5048646352 @default.
• W2159794252 creator A5069181978 @default.
• W2159794252 creator A5080663316 @default.
• W2159794252 creator A5083408464 @default.
• W2159794252 date "2004-08-01" @default.
• W2159794252 modified "2023-10-12" @default.
• W2159794252 title "Increased Levels of Wee-1 Kinase in G 2 Are Necessary for Vpr- and Gamma Irradiation-Induced G 2 Arrest" @default.
• W2159794252 cites W1480448067 @default.
• W2159794252 cites W1511997451 @default.
• W2159794252 cites W1524628399 @default.
• W2159794252 cites W1540165068 @default.
• W2159794252 cites W1611419331 @default.
• W2159794252 cites W1744830096 @default.
• W2159794252 cites W1853269105 @default.
• W2159794252 cites W1925504181 @default.
• W2159794252 cites W1982821013 @default.
• W2159794252 cites W1992848268 @default.
• W2159794252 cites W2010051771 @default.
• W2159794252 cites W2010840723 @default.
• W2159794252 cites W2038340312 @default.
• W2159794252 cites W2048731959 @default.
• W2159794252 cites W2069574267 @default.
• W2159794252 cites W2072901265 @default.
• W2159794252 cites W2073578569 @default.
• W2159794252 cites W2074633316 @default.
• W2159794252 cites W2086131247 @default.
• W2159794252 cites W2098625990 @default.
• W2159794252 cites W2108498026 @default.
• W2159794252 cites W2108779766 @default.
• W2159794252 cites W2109324904 @default.
• W2159794252 cites W2124389350 @default.
• W2159794252 cites W2124585743 @default.
• W2159794252 cites W2136277289 @default.
• W2159794252 cites W2137922559 @default.
• W2159794252 cites W2143404342 @default.
• W2159794252 cites W2150514496 @default.
• W2159794252 cites W2159113944 @default.
• W2159794252 cites W2169601134 @default.
• W2159794252 cites W2171251720 @default.
• W2159794252 cites W63001887 @default.
• W2159794252 doi "https://doi.org/10.1128/jvi.78.15.8183-8190.2004" @default.
• W2159794252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/446131" @default.
• W2159794252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15254189" @default.
• W2159794252 hasPublicationYear "2004" @default.
• W2159794252 type Work @default.
• W2159794252 sameAs 2159794252 @default.
• W2159794252 citedByCount "43" @default.
• W2159794252 countsByYear W21597942522012 @default.
• W2159794252 countsByYear W21597942522014 @default.
• W2159794252 countsByYear W21597942522017 @default.
• W2159794252 countsByYear W21597942522018 @default.
• W2159794252 countsByYear W21597942522019 @default.
• W2159794252 crossrefType "journal-article" @default.
• W2159794252 hasAuthorship W2159794252A5048646352 @default.
• W2159794252 hasAuthorship W2159794252A5069181978 @default.
• W2159794252 hasAuthorship W2159794252A5080663316 @default.
• W2159794252 hasAuthorship W2159794252A5083408464 @default.
• W2159794252 hasBestOaLocation W21597942521 @default.
• W2159794252 hasConcept C104317684 @default.
• W2159794252 hasConcept C105696609 @default.
• W2159794252 hasConcept C120504264 @default.
• W2159794252 hasConcept C153911025 @default.
• W2159794252 hasConcept C184235292 @default.
• W2159794252 hasConcept C190283241 @default.
• W2159794252 hasConcept C22615655 @default.
• W2159794252 hasConcept C2781252693 @default.
• W2159794252 hasConcept C29537977 @default.
• W2159794252 hasConcept C55493867 @default.
• W2159794252 hasConcept C62478195 @default.
• W2159794252 hasConcept C67705224 @default.
• W2159794252 hasConcept C86803240 @default.
• W2159794252 hasConcept C93304396 @default.
• W2159794252 hasConcept C95444343 @default.
• W2159794252 hasConceptScore W2159794252C104317684 @default.
• W2159794252 hasConceptScore W2159794252C105696609 @default.
• W2159794252 hasConceptScore W2159794252C120504264 @default.
• W2159794252 hasConceptScore W2159794252C153911025 @default.
• W2159794252 hasConceptScore W2159794252C184235292 @default.
• W2159794252 hasConceptScore W2159794252C190283241 @default.
• W2159794252 hasConceptScore W2159794252C22615655 @default.
• W2159794252 hasConceptScore W2159794252C2781252693 @default.
• W2159794252 hasConceptScore W2159794252C29537977 @default.
• W2159794252 hasConceptScore W2159794252C55493867 @default.
• W2159794252 hasConceptScore W2159794252C62478195 @default.
• W2159794252 hasConceptScore W2159794252C67705224 @default.
• W2159794252 hasConceptScore W2159794252C86803240 @default.
• W2159794252 hasConceptScore W2159794252C93304396 @default.
• W2159794252 hasConceptScore W2159794252C95444343 @default.
• W2159794252 hasIssue "15" @default.
• W2159794252 hasLocation W21597942521 @default.
• W2159794252 hasLocation W21597942522 @default.
• W2159794252 hasLocation W21597942523 @default.
• W2159794252 hasLocation W21597942524 @default.
• W2159794252 hasOpenAccess W2159794252 @default.
• W2159794252 hasPrimaryLocation W21597942521 @default.
• W2159794252 hasRelatedWork W117839809 @default.

• next