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- W2159799021 abstract "Rapid antigen detection tests (ADTs) are promoted for identification of group A streptococci (GAS) in the upper respiratory tract. Although debate persists about their sensitivity, most investigators consider ADTs to be highly specific. Nevertheless, reports continue to describe false-positive ADT results (positive ADT result, negative culture result). This study examined culture results from 522 adult patients with acute pharyngitis and a positive ADT result; unexpectedly, 15% had throat culture results negative for GAS. Normal bacterial flora from 30% of these negative culture results produced a positive ADT result. An ADT-reactive organism belonging to the Streptococcus milleri group was isolated from 1 culture; it carried group A carbohydrate antigen. Although S. milleri previously has been associated with false-positive ADT reactions, the frequency of this phenomenon is unknown. The present, large study suggests that false-positive ADT reactions may be more common than previously reported, an observation that must be precisely explained and epidemiologically and clinically defined." @default.
- W2159799021 created "2016-06-24" @default.
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- W2159799021 date "2001-04-01" @default.
- W2159799021 modified "2023-09-30" @default.
- W2159799021 title "False‐Positive Rapid Antigen Detection Test Results: Reduced Specificity in the Absence of Group A Streptococci in the Upper Respiratory Tract" @default.
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- W2159799021 doi "https://doi.org/10.1086/319286" @default.
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