Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159810329> ?p ?o ?g. }
- W2159810329 endingPage "1118" @default.
- W2159810329 startingPage "1093" @default.
- W2159810329 abstract "Introduction: The genetic background of antidepressant response represents a unique opportunity to identify biological markers of treatment outcome. Encouraging results alternating with inconsistent findings made antidepressant pharmacogenetics a stimulating but often discouraging field that requires careful discussion about cumulative evidence and methodological issues.Areas covered: The present review discusses both known and less replicated genes that have been implicated in selective serotonin reuptake inhibitors (SSRIs) efficacy and side effects. Candidate genes studies and genome-wide association studies (GWAS) were collected through MEDLINE database search (articles published till January 2014). Further, GWAS signals localized in promising genetic regions according to candidate gene studies are reported in order to assess the general comparability of results obtained through these two types of pharmacogenetic studies. Finally, a pathway enrichment approach is applied to the top genes (those harboring SNPs with p < 0.0001) outlined by previous GWAS in order to identify possible molecular mechanisms involved in SSRI effect.Expert opinion: In order to improve the understanding of SSRI pharmacogenetics, the present review discusses the proposal of moving from the analysis of individual polymorphisms to genes and molecular pathways, and from the separation across different methodological approaches to their combination. Efforts in this direction are justified by the recent evidence of a favorable cost-utility of gene-guided antidepressant treatment." @default.
- W2159810329 created "2016-06-24" @default.
- W2159810329 creator A5008897343 @default.
- W2159810329 creator A5034956936 @default.
- W2159810329 creator A5035014294 @default.
- W2159810329 creator A5062596209 @default.
- W2159810329 date "2014-06-14" @default.
- W2159810329 modified "2023-09-23" @default.
- W2159810329 title "Understanding the pharmacogenetics of selective serotonin reuptake inhibitors" @default.
- W2159810329 cites W1501777540 @default.
- W2159810329 cites W1508588021 @default.
- W2159810329 cites W1566894902 @default.
- W2159810329 cites W1751728186 @default.
- W2159810329 cites W1834926699 @default.
- W2159810329 cites W1903514606 @default.
- W2159810329 cites W191982317 @default.
- W2159810329 cites W1965401688 @default.
- W2159810329 cites W1966000037 @default.
- W2159810329 cites W1966042629 @default.
- W2159810329 cites W1966669480 @default.
- W2159810329 cites W1969391575 @default.
- W2159810329 cites W1970188324 @default.
- W2159810329 cites W1970506215 @default.
- W2159810329 cites W1970674565 @default.
- W2159810329 cites W1972243139 @default.
- W2159810329 cites W1972663341 @default.
- W2159810329 cites W1973178798 @default.
- W2159810329 cites W1977160269 @default.
- W2159810329 cites W1977949510 @default.
- W2159810329 cites W1978742008 @default.
- W2159810329 cites W1979645066 @default.
- W2159810329 cites W1979782032 @default.
- W2159810329 cites W1979881878 @default.
- W2159810329 cites W1979894286 @default.
- W2159810329 cites W1980437773 @default.
- W2159810329 cites W1981364522 @default.
- W2159810329 cites W1981684805 @default.
- W2159810329 cites W1981734883 @default.
- W2159810329 cites W1984615306 @default.
- W2159810329 cites W1984802541 @default.
- W2159810329 cites W1991924547 @default.
- W2159810329 cites W1993877523 @default.
- W2159810329 cites W1994395341 @default.
- W2159810329 cites W1994516975 @default.
- W2159810329 cites W1995331205 @default.
- W2159810329 cites W1996711980 @default.
- W2159810329 cites W1999884255 @default.
- W2159810329 cites W2000793737 @default.
- W2159810329 cites W2001044475 @default.
- W2159810329 cites W2001135666 @default.
- W2159810329 cites W2001279805 @default.
- W2159810329 cites W2001585610 @default.
- W2159810329 cites W2002470967 @default.
- W2159810329 cites W2003470167 @default.
- W2159810329 cites W2004588635 @default.
- W2159810329 cites W2005524713 @default.
- W2159810329 cites W2005539285 @default.
- W2159810329 cites W2007139949 @default.
- W2159810329 cites W2007379387 @default.
- W2159810329 cites W2007651149 @default.
- W2159810329 cites W2008709814 @default.
- W2159810329 cites W2008933847 @default.
- W2159810329 cites W2009966911 @default.
- W2159810329 cites W2010383926 @default.
- W2159810329 cites W2010870870 @default.
- W2159810329 cites W2012579750 @default.
- W2159810329 cites W2015574768 @default.
- W2159810329 cites W2016325373 @default.
- W2159810329 cites W2016364360 @default.
- W2159810329 cites W2016461535 @default.
- W2159810329 cites W2016650069 @default.
- W2159810329 cites W2018041498 @default.
- W2159810329 cites W2019304428 @default.
- W2159810329 cites W2021097680 @default.
- W2159810329 cites W2021198303 @default.
- W2159810329 cites W2022699528 @default.
- W2159810329 cites W2023866167 @default.
- W2159810329 cites W2024012851 @default.
- W2159810329 cites W2026622088 @default.
- W2159810329 cites W2028145209 @default.
- W2159810329 cites W2028551045 @default.
- W2159810329 cites W2028688777 @default.
- W2159810329 cites W2029595576 @default.
- W2159810329 cites W2029821777 @default.
- W2159810329 cites W2030026084 @default.
- W2159810329 cites W2030501710 @default.
- W2159810329 cites W2031690017 @default.
- W2159810329 cites W2033042874 @default.
- W2159810329 cites W2034287575 @default.
- W2159810329 cites W2035090322 @default.
- W2159810329 cites W2037500185 @default.
- W2159810329 cites W2038189978 @default.
- W2159810329 cites W2038316458 @default.
- W2159810329 cites W2039370934 @default.
- W2159810329 cites W2039531403 @default.
- W2159810329 cites W2040699021 @default.
- W2159810329 cites W2043175890 @default.
- W2159810329 cites W2043432295 @default.