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- W2159848936 abstract "Enteric neuropathy is emerging as a central theme in a range of digestive tract pathologies. Aberrant nitric ox- ide (NO) signaling by cellular components of the enteric nervous system or by inappropriate processing of dietary nitrite represents potential disease factors in delayed gastric emptying, diabetic gastroparesis, hypertrophic pyloric stenosis, and in inflammatory barrier dysfunction of the gut. Exploiting the neuronal nitric oxide synthase (nNOS) system to generate NO as a form of treatment is considered an option in these clinical disorders. Here we review the transcriptional regula- tion of nNOS activity and its pathophysiological role in the digestive tract. We also highlight potentially novel therapeutic strategies that exploit nNOS-derived S-nitrosothiols (SNO) and advanced glycation end products (AGEs)." @default.
- W2159848936 created "2016-06-24" @default.
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- W2159848936 date "2008-04-07" @default.
- W2159848936 modified "2023-10-15" @default.
- W2159848936 title "Enteric Neuropathy: NO, SNO in AGEs" @default.
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- W2159848936 doi "https://doi.org/10.2174/1874259900802010011" @default.
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