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• W2159849016 abstract "<h3>Background</h3> Apolipoprotein E is polymorphic in the human population. <i>APOE4</i> has previously been reported to correlate with symptomatic oral and genital herpes disease. <h3>Methods</h3> <i>APOE</i> was genotyped in 182 subjects with herpes simplex virus (HSV) 2 and in 62 subjects with HSV-1, including 44 subjects with both viral types for a total of 200 adults. HSV shedding was measured by PCR from swab samples obtained daily from mucosa for at least 30 days. Participants also maintained a diary of oral or genital lesions. <h3>Results</h3> The <i>APOE</i> genotypes observed reflected the US white population and the Hardy–Weinberg equilibrium. Genital and oral HSV shedding was detected on 17.2% and 3.7% of overall days, respectively, whereas genital and oral lesion rates were 10.1% and 2.9%. Using Poisson regression and adjusting for known correlates of HSV shedding, a significant association was not observed between the <i>APOE</i> genotype and genital or oral HSV shedding, or genital HSV lesions. However, the presence of the <i>APOE4</i> allele was associated with a higher rate of oral herpetic lesions, with a relative risk of 4.64 (95% CI 1.32 to 15.05, p=0.016). <h3>Conclusions</h3> Variation at the <i>APOE</i> locus may be associated with clinical manifestations of HSV-1 infection, but does not appear to correlate with herpes simplex viral reactivation in humans." @default.
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• W2159849016 date "2010-04-21" @default.
• W2159849016 modified "2023-10-17" @default.
• W2159849016 title "APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding" @default.
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• W2159849016 doi "https://doi.org/10.1136/sti.2009.039735" @default.
• W2159849016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881187" @default.
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