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• W2159896505 abstract "Distributive conjugal transfer (DCT) is a newly described mechanism of lateral gene transfer (LGT) that results in a mosaic transconjugant structure, similar to the products of meiosis. We have tested popular LGT detection methods on whole-genome sequence data from experimental DCT transconjugants and used the best performing methods to compare genomic signatures of DCT with those of LGT through natural transformation, conjugative plasmids, and mobile genetic elements (MGE). We found that DCT results in transfer of larger chromosomal segments, that these segments are distributed more broadly around the chromosome, and that a greater proportion of the chromosome is affected by DCT than by other mechanisms of LGT. We used the best performing methods to characterize LGT in Mycobacterium canettii , the mycobacterial species most closely related to Mycobacterium tuberculosis . Patterns of LGT among M. canettii were highly distinctive. Gene flow appeared unidirectional, from lineages with minimal evidence of LGT to isolates with a substantial proportion (6–13%) of sites identified as recombinant. Among M. canettii isolates with evidence of LGT, recombinant fragments were larger and more evenly distributed relative to bacteria that undergo LGT through natural transformation, conjugative plasmids, and MGE. Spatial bias in M. canettii was also unusual in that patterns of recombinant fragment sharing mirrored overall phylogenetic structure. Based on the proportion of recombinant sites, the size of recombinant fragments, their spatial distribution and lack of association with MGE, as well as unidirectionality of DNA transfer, we conclude that DCT is the predominant mechanism of LGT among M. canettii ." @default.
• W2159896505 created "2016-06-24" @default.
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• W2159896505 date "2014-08-30" @default.
• W2159896505 modified "2023-09-27" @default.
• W2159896505 title "Genomic Signatures of Distributive Conjugal Transfer among Mycobacteria" @default.
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• W2159896505 doi "https://doi.org/10.1093/gbe/evu175" @default.
• W2159896505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4202316" @default.
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