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• W2159898469 abstract "Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria, and if yes, set up a standard protocol for preparing the herbal tea.The leaf tea was extracted with methylene chloride and the organic extract was fractionated with HPLC. Pure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined.We discovered that antimalarial Quassia amara young leaf tea contains several quassinoids: simalikalactone D (SkD, 1), picrasin B (2), picrasin H (3), neoquassin (4), quassin (5), picrasin I (6) and picrasin J (7). These last two compounds are new. In addition, our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD.In conclusion, this preparation should not be recommended for treatment of malaria until a clinical study in humans is performed with SkD." @default.
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• W2159898469 date "2009-10-01" @default.
• W2159898469 modified "2023-10-17" @default.
• W2159898469 title "Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity" @default.
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• W2159898469 doi "https://doi.org/10.1016/j.jep.2009.07.037" @default.
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