Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159908493> ?p ?o ?g. }
- W2159908493 abstract "Glucocorticoids (GC) are the most commonly prescribed medications for patients with inflammatory diseases, despite their well-known adverse metabolic effects. Previously, it was understood that the anti-inflammatory effects of the GC/GC receptor (GR) complex were mediated via transrepression, whilst the adverse metabolic effects were mediated via transactivation. It has recently become clear that this divergent actions paradigm of GC actions is likely insufficient. It has been reported that the GC/GR-mediated transactivation also contributes to the anti-inflammatory actions of GC, via up-regulation of key anti-inflammatory proteins. One of these is glucocorticoid-induced leucine zipper (GILZ), which inhibits inflammatory responses in a number of important immune cell lineages in vitro, as well as in animal models of inflammatory diseases in vivo. This review aims to compare the GILZ and GC effects on specific cell lineages and animal models of inflammatory diseases. The fact that the actions of GILZ permit a GILZ-based gene therapy to lack GC-like adverse effects presents the potential for development of new strategies to treat patients with inflammatory diseases." @default.
- W2159908493 created "2016-06-24" @default.
- W2159908493 creator A5036855659 @default.
- W2159908493 creator A5051150428 @default.
- W2159908493 creator A5087586345 @default.
- W2159908493 date "2014-07-17" @default.
- W2159908493 modified "2023-10-13" @default.
- W2159908493 title "Development of novel treatment strategies for inflammatory diseases—similarities and divergence between glucocorticoids and GILZ" @default.
- W2159908493 cites W1522773084 @default.
- W2159908493 cites W1552751328 @default.
- W2159908493 cites W1559184092 @default.
- W2159908493 cites W1563808745 @default.
- W2159908493 cites W1599826635 @default.
- W2159908493 cites W1841040774 @default.
- W2159908493 cites W1858954343 @default.
- W2159908493 cites W1877755747 @default.
- W2159908493 cites W1885181261 @default.
- W2159908493 cites W1885902605 @default.
- W2159908493 cites W1894066899 @default.
- W2159908493 cites W1903165832 @default.
- W2159908493 cites W1951353479 @default.
- W2159908493 cites W1968932167 @default.
- W2159908493 cites W1972068895 @default.
- W2159908493 cites W1974265619 @default.
- W2159908493 cites W1987930967 @default.
- W2159908493 cites W1990734073 @default.
- W2159908493 cites W1991609774 @default.
- W2159908493 cites W1994984573 @default.
- W2159908493 cites W1995389009 @default.
- W2159908493 cites W1996740963 @default.
- W2159908493 cites W2000504729 @default.
- W2159908493 cites W2002315967 @default.
- W2159908493 cites W2002519246 @default.
- W2159908493 cites W2005268742 @default.
- W2159908493 cites W2005698033 @default.
- W2159908493 cites W2008244058 @default.
- W2159908493 cites W2008654807 @default.
- W2159908493 cites W2009753649 @default.
- W2159908493 cites W2009801071 @default.
- W2159908493 cites W2011057086 @default.
- W2159908493 cites W2017916832 @default.
- W2159908493 cites W2018508671 @default.
- W2159908493 cites W2021794070 @default.
- W2159908493 cites W2022672527 @default.
- W2159908493 cites W2023702942 @default.
- W2159908493 cites W2025019393 @default.
- W2159908493 cites W2030295027 @default.
- W2159908493 cites W2035038614 @default.
- W2159908493 cites W2035809865 @default.
- W2159908493 cites W2037882509 @default.
- W2159908493 cites W2043066069 @default.
- W2159908493 cites W2044512117 @default.
- W2159908493 cites W2045279683 @default.
- W2159908493 cites W2046571738 @default.
- W2159908493 cites W2048316119 @default.
- W2159908493 cites W2053125671 @default.
- W2159908493 cites W2054115898 @default.
- W2159908493 cites W2054870010 @default.
- W2159908493 cites W2056570842 @default.
- W2159908493 cites W2058212353 @default.
- W2159908493 cites W2061444689 @default.
- W2159908493 cites W2062447638 @default.
- W2159908493 cites W2062512887 @default.
- W2159908493 cites W2063861465 @default.
- W2159908493 cites W2064936324 @default.
- W2159908493 cites W2065742608 @default.
- W2159908493 cites W2066022850 @default.
- W2159908493 cites W2067181732 @default.
- W2159908493 cites W2068198033 @default.
- W2159908493 cites W2075288153 @default.
- W2159908493 cites W2076763303 @default.
- W2159908493 cites W2078517814 @default.
- W2159908493 cites W2081005510 @default.
- W2159908493 cites W2081305653 @default.
- W2159908493 cites W2083104211 @default.
- W2159908493 cites W2083493178 @default.
- W2159908493 cites W2083640512 @default.
- W2159908493 cites W2083719502 @default.
- W2159908493 cites W2084564714 @default.
- W2159908493 cites W2087669700 @default.
- W2159908493 cites W2090267463 @default.
- W2159908493 cites W2092134437 @default.
- W2159908493 cites W2095345745 @default.
- W2159908493 cites W2096353975 @default.
- W2159908493 cites W2096820421 @default.
- W2159908493 cites W2099807030 @default.
- W2159908493 cites W2104464991 @default.
- W2159908493 cites W2106712145 @default.
- W2159908493 cites W2110114520 @default.
- W2159908493 cites W2110670037 @default.
- W2159908493 cites W2112522175 @default.
- W2159908493 cites W2112687470 @default.
- W2159908493 cites W2114589605 @default.
- W2159908493 cites W2119593016 @default.
- W2159908493 cites W2124359549 @default.
- W2159908493 cites W2128864178 @default.
- W2159908493 cites W2131791979 @default.
- W2159908493 cites W2132254923 @default.
- W2159908493 cites W2136242443 @default.
- W2159908493 cites W2141546803 @default.