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• W2159909265 abstract "PML-RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications." @default.
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• W2159909265 date "2011-01-18" @default.
• W2159909265 modified "2023-10-10" @default.
• W2159909265 title "Genome-wide functions of PML–RARα in acute promyelocytic leukaemia" @default.
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• W2159909265 doi "https://doi.org/10.1038/sj.bjc.6606095" @default.
• W2159909265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3049592" @default.
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