Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159969192> ?p ?o ?g. }
- W2159969192 endingPage "1087" @default.
- W2159969192 startingPage "1079" @default.
- W2159969192 abstract "The transcription factor Microphthalmia-associated transcription factor (MITF) is a lineage-determination factor, which modulates melanocyte differentiation and pigmentation. MITF was recently shown to reside downstream of the canonical Wnt pathway during melanocyte differentiation from pluripotent neural crest cells in zebrafish as well as in mammalian melanocyte lineage cells. Although expression of many melanocytic/pigmentation markers is lost in human melanoma, MITF expression remains intact, even in unpigmented tumors, suggesting a role for MITF beyond its role in differentiation. A significant fraction of primary human melanomas exhibit deregulation (via aberrant nuclear accumulation) of beta-catenin, leading us to examine its role in melanoma growth and survival. Here, we show that beta-catenin is a potent mediator of growth for melanoma cells in a manner dependent on its downstream target MITF. Moreover, suppression of melanoma clonogenic growth by disruption of beta-catenin-T-cell transcription factor/LEF is rescued by constitutive MITF. This rescue occurs largely through a prosurvival mechanism. Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm." @default.
- W2159969192 created "2016-06-24" @default.
- W2159969192 creator A5000021060 @default.
- W2159969192 creator A5022764850 @default.
- W2159969192 creator A5024275910 @default.
- W2159969192 creator A5032142783 @default.
- W2159969192 creator A5066230987 @default.
- W2159969192 creator A5072619195 @default.
- W2159969192 creator A5078874539 @default.
- W2159969192 creator A5086032916 @default.
- W2159969192 date "2002-09-16" @default.
- W2159969192 modified "2023-10-12" @default.
- W2159969192 title "β-Catenin–induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor" @default.
- W2159969192 cites W1493098692 @default.
- W2159969192 cites W1554815317 @default.
- W2159969192 cites W1611895582 @default.
- W2159969192 cites W1667206495 @default.
- W2159969192 cites W1880606548 @default.
- W2159969192 cites W1963091570 @default.
- W2159969192 cites W1963652662 @default.
- W2159969192 cites W1968366612 @default.
- W2159969192 cites W1987047126 @default.
- W2159969192 cites W1999455762 @default.
- W2159969192 cites W2002404925 @default.
- W2159969192 cites W2002918515 @default.
- W2159969192 cites W2029857102 @default.
- W2159969192 cites W2032044707 @default.
- W2159969192 cites W2034030391 @default.
- W2159969192 cites W2051718122 @default.
- W2159969192 cites W2062595374 @default.
- W2159969192 cites W2068252839 @default.
- W2159969192 cites W2073772356 @default.
- W2159969192 cites W2078337982 @default.
- W2159969192 cites W2081620539 @default.
- W2159969192 cites W2090364563 @default.
- W2159969192 cites W2091605975 @default.
- W2159969192 cites W2102955245 @default.
- W2159969192 cites W2103597610 @default.
- W2159969192 cites W2107006976 @default.
- W2159969192 cites W2108175127 @default.
- W2159969192 cites W2109069210 @default.
- W2159969192 cites W2122711551 @default.
- W2159969192 cites W2125842849 @default.
- W2159969192 cites W2126638912 @default.
- W2159969192 cites W2130987003 @default.
- W2159969192 cites W2142522741 @default.
- W2159969192 cites W2145297890 @default.
- W2159969192 cites W2146167376 @default.
- W2159969192 cites W2159299286 @default.
- W2159969192 cites W2159522663 @default.
- W2159969192 cites W2165061154 @default.
- W2159969192 cites W2165685789 @default.
- W2159969192 cites W2170839692 @default.
- W2159969192 cites W2239090104 @default.
- W2159969192 cites W4250635458 @default.
- W2159969192 doi "https://doi.org/10.1083/jcb.200202049" @default.
- W2159969192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2173224" @default.
- W2159969192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12235125" @default.
- W2159969192 hasPublicationYear "2002" @default.
- W2159969192 type Work @default.
- W2159969192 sameAs 2159969192 @default.
- W2159969192 citedByCount "257" @default.
- W2159969192 countsByYear W21599691922012 @default.
- W2159969192 countsByYear W21599691922013 @default.
- W2159969192 countsByYear W21599691922014 @default.
- W2159969192 countsByYear W21599691922015 @default.
- W2159969192 countsByYear W21599691922016 @default.
- W2159969192 countsByYear W21599691922017 @default.
- W2159969192 countsByYear W21599691922018 @default.
- W2159969192 countsByYear W21599691922019 @default.
- W2159969192 countsByYear W21599691922020 @default.
- W2159969192 countsByYear W21599691922021 @default.
- W2159969192 countsByYear W21599691922022 @default.
- W2159969192 countsByYear W21599691922023 @default.
- W2159969192 crossrefType "journal-article" @default.
- W2159969192 hasAuthorship W2159969192A5000021060 @default.
- W2159969192 hasAuthorship W2159969192A5022764850 @default.
- W2159969192 hasAuthorship W2159969192A5024275910 @default.
- W2159969192 hasAuthorship W2159969192A5032142783 @default.
- W2159969192 hasAuthorship W2159969192A5066230987 @default.
- W2159969192 hasAuthorship W2159969192A5072619195 @default.
- W2159969192 hasAuthorship W2159969192A5078874539 @default.
- W2159969192 hasAuthorship W2159969192A5086032916 @default.
- W2159969192 hasBestOaLocation W21599691921 @default.
- W2159969192 hasConcept C104317684 @default.
- W2159969192 hasConcept C126749454 @default.
- W2159969192 hasConcept C137620995 @default.
- W2159969192 hasConcept C177504595 @default.
- W2159969192 hasConcept C196843134 @default.
- W2159969192 hasConcept C2776878037 @default.
- W2159969192 hasConcept C2777658100 @default.
- W2159969192 hasConcept C2778085061 @default.
- W2159969192 hasConcept C2779324961 @default.
- W2159969192 hasConcept C2779769559 @default.
- W2159969192 hasConcept C502942594 @default.
- W2159969192 hasConcept C54355233 @default.
- W2159969192 hasConcept C62478195 @default.
- W2159969192 hasConcept C86339819 @default.