Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159969334> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2159969334 endingPage "86" @default.
- W2159969334 startingPage "80" @default.
- W2159969334 abstract "Electrical stimulation of crayfish giant axons at high frequency activates group II metabotropic and NMDA glutamate receptors on adjacent glial cells via release of N-acetylaspartylglutamate and glutamate formed upon its hydrolysis. This produces a transient depolarization followed by a prolonged hyperpolarization of glial cells that involves nicotinic acetylcholine receptor activation. The hyperpolarization is nearly completely blocked by antagonists of metabotropic glutamate receptors but only slightly reduced by inhibition of NMDA receptors. We report that the NMDA-induced hyperpolarization of glial cells is reduced by decreased calcium in the solution bathing the giant nerve fiber, while removal of sodium ions or block of voltage-dependent calcium channels completely prevents the glial response to NMDA. Inhibition of nicotinic acetylcholine receptors or removal of extracellular Cl(-) converts the glial response from a hyperpolarization to a depolarization that is sensitive to NMDA receptor antagonist. We propose that NMDA receptor activation by glutamate, formed from extracellular N-acetylaspartylglutamate during nerve stimulation, contributes to glial hyperpolarization by increasing intracellular Ca(2+) via opening of voltage-sensitive Ca(2+) channels. Based on our previous work, we propose further that the added Ca(2+) supplements that produced by N-acetylaspartylglutamate and glutamate acting on group II metabotropic glutamate receptors to cause an increased release of acetylcholine and a larger hyperpolarization." @default.
- W2159969334 created "2016-06-24" @default.
- W2159969334 creator A5008684159 @default.
- W2159969334 creator A5031447480 @default.
- W2159969334 creator A5068774560 @default.
- W2159969334 creator A5088578730 @default.
- W2159969334 date "2002-02-25" @default.
- W2159969334 modified "2023-10-09" @default.
- W2159969334 title "Mechanism of NMDA receptor contribution to axon-to-glia signaling in the crayfish medial giant nerve fiber" @default.
- W2159969334 cites W1499385977 @default.
- W2159969334 cites W1834805773 @default.
- W2159969334 cites W1969080564 @default.
- W2159969334 cites W1974617672 @default.
- W2159969334 cites W1975317646 @default.
- W2159969334 cites W1980803132 @default.
- W2159969334 cites W1991052080 @default.
- W2159969334 cites W1994057279 @default.
- W2159969334 cites W1995056605 @default.
- W2159969334 cites W2019487067 @default.
- W2159969334 cites W2020648457 @default.
- W2159969334 cites W2023153550 @default.
- W2159969334 cites W2028775325 @default.
- W2159969334 cites W2041373139 @default.
- W2159969334 cites W2046555983 @default.
- W2159969334 cites W2050416880 @default.
- W2159969334 cites W2057537207 @default.
- W2159969334 cites W2077497516 @default.
- W2159969334 cites W2078199061 @default.
- W2159969334 cites W2079822716 @default.
- W2159969334 cites W2143662283 @default.
- W2159969334 cites W2334685436 @default.
- W2159969334 cites W4242930701 @default.
- W2159969334 cites W4324262882 @default.
- W2159969334 doi "https://doi.org/10.1002/glia.10042" @default.
- W2159969334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11921205" @default.
- W2159969334 hasPublicationYear "2002" @default.
- W2159969334 type Work @default.
- W2159969334 sameAs 2159969334 @default.
- W2159969334 citedByCount "6" @default.
- W2159969334 countsByYear W21599693342014 @default.
- W2159969334 countsByYear W21599693342016 @default.
- W2159969334 countsByYear W21599693342019 @default.
- W2159969334 countsByYear W21599693342021 @default.
- W2159969334 crossrefType "journal-article" @default.
- W2159969334 hasAuthorship W2159969334A5008684159 @default.
- W2159969334 hasAuthorship W2159969334A5031447480 @default.
- W2159969334 hasAuthorship W2159969334A5068774560 @default.
- W2159969334 hasAuthorship W2159969334A5088578730 @default.
- W2159969334 hasConcept C12554922 @default.
- W2159969334 hasConcept C131453863 @default.
- W2159969334 hasConcept C169760540 @default.
- W2159969334 hasConcept C170493617 @default.
- W2159969334 hasConcept C178790620 @default.
- W2159969334 hasConcept C185592680 @default.
- W2159969334 hasConcept C26702167 @default.
- W2159969334 hasConcept C49051014 @default.
- W2159969334 hasConcept C55493867 @default.
- W2159969334 hasConcept C61174792 @default.
- W2159969334 hasConcept C66974803 @default.
- W2159969334 hasConcept C67018056 @default.
- W2159969334 hasConcept C86803240 @default.
- W2159969334 hasConcept C95444343 @default.
- W2159969334 hasConceptScore W2159969334C12554922 @default.
- W2159969334 hasConceptScore W2159969334C131453863 @default.
- W2159969334 hasConceptScore W2159969334C169760540 @default.
- W2159969334 hasConceptScore W2159969334C170493617 @default.
- W2159969334 hasConceptScore W2159969334C178790620 @default.
- W2159969334 hasConceptScore W2159969334C185592680 @default.
- W2159969334 hasConceptScore W2159969334C26702167 @default.
- W2159969334 hasConceptScore W2159969334C49051014 @default.
- W2159969334 hasConceptScore W2159969334C55493867 @default.
- W2159969334 hasConceptScore W2159969334C61174792 @default.
- W2159969334 hasConceptScore W2159969334C66974803 @default.
- W2159969334 hasConceptScore W2159969334C67018056 @default.
- W2159969334 hasConceptScore W2159969334C86803240 @default.
- W2159969334 hasConceptScore W2159969334C95444343 @default.
- W2159969334 hasIssue "1" @default.
- W2159969334 hasLocation W21599693341 @default.
- W2159969334 hasLocation W21599693342 @default.
- W2159969334 hasOpenAccess W2159969334 @default.
- W2159969334 hasPrimaryLocation W21599693341 @default.
- W2159969334 hasRelatedWork W1974963742 @default.
- W2159969334 hasRelatedWork W1982221956 @default.
- W2159969334 hasRelatedWork W1985121678 @default.
- W2159969334 hasRelatedWork W1994493437 @default.
- W2159969334 hasRelatedWork W2005678155 @default.
- W2159969334 hasRelatedWork W2094568064 @default.
- W2159969334 hasRelatedWork W2357841647 @default.
- W2159969334 hasRelatedWork W2746657404 @default.
- W2159969334 hasRelatedWork W2950173340 @default.
- W2159969334 hasRelatedWork W829698206 @default.
- W2159969334 hasVolume "38" @default.
- W2159969334 isParatext "false" @default.
- W2159969334 isRetracted "false" @default.
- W2159969334 magId "2159969334" @default.
- W2159969334 workType "article" @default.