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• W2159969892 abstract "Galectin, an animal lectin that recognizes β-galactoside of glycoconjugates, is abundant in the gut. This IHC study showed the subtype-specific localization of galectin in the mouse digestive tract. Mucosal epithelium showed region/cell-specific localization of each galectin subtype. Gastric mucous cells exhibited intense immunoreactions for galectin-2 and galectin-4/6 with a limited localization of galectin-3 at the surface of the gastric mucosa. Electron microscopically, galectin-3 immunoreactivity coated indigenous bacteria on the gastric surface mucous cells. Epithelial cells in the small intestine showed characteristic localizations of galectin-2 and galectin-4/6 in the cytoplasm of goblet cells and the baso-lateral membrane of enterocytes in association with maturation, respectively. Galectin-3 expressed only at the villus tips was concentrated at the myosin-rich terminal web of fully matured enterocytes. Epithelial cells of the large intestine contained intense immunoreactions for galectin-3 and galectin-4/6 but not for galectin-2. The stratified squamous epithelium of the forestomach was immunoreactive for galectin-3 and galectin-7, but the basal layer lacked galectin-3 immunoreactivity. Outside the epithelium, only galectin-1 was localized in the connective tissue, smooth muscles, and neuronal cell bodies. The subtype-specific localization of galectin suggests its important roles in host-pathogen interaction and epithelial homeostasis such as membrane polarization and trafficking in the gut." @default.
• W2159969892 created "2016-06-24" @default.
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• W2159969892 creator A5090447505 @default.
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• W2159969892 date "2008-09-15" @default.
• W2159969892 modified "2023-10-16" @default.
• W2159969892 title "Immunohistochemical Localization of Six Galectin Subtypes in the Mouse Digestive Tract" @default.
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• W2159969892 doi "https://doi.org/10.1369/jhc.2008.952317" @default.
• W2159969892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2605710" @default.
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