Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159999251> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2159999251 endingPage "1316" @default.
- W2159999251 startingPage "1313" @default.
- W2159999251 abstract "Cdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify five novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with a known inhibitor scaffold. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail." @default.
- W2159999251 created "2016-06-24" @default.
- W2159999251 creator A5005934892 @default.
- W2159999251 creator A5013462262 @default.
- W2159999251 creator A5017742425 @default.
- W2159999251 creator A5024729840 @default.
- W2159999251 creator A5038468542 @default.
- W2159999251 creator A5055386073 @default.
- W2159999251 date "2009-06-20" @default.
- W2159999251 modified "2023-09-26" @default.
- W2159999251 title "Discovery of Novel and Potent Cdc25 Phosphatase Inhibitors Based on the Structure-Based De Novo Design" @default.
- W2159999251 cites W1966993792 @default.
- W2159999251 cites W1969358010 @default.
- W2159999251 cites W1982629919 @default.
- W2159999251 cites W1990830210 @default.
- W2159999251 cites W1999676304 @default.
- W2159999251 cites W2000770819 @default.
- W2159999251 cites W2008517160 @default.
- W2159999251 cites W2011230643 @default.
- W2159999251 cites W2030381529 @default.
- W2159999251 cites W2035399289 @default.
- W2159999251 cites W2038547069 @default.
- W2159999251 cites W2057124829 @default.
- W2159999251 cites W2081708131 @default.
- W2159999251 cites W2089473708 @default.
- W2159999251 cites W2093161171 @default.
- W2159999251 cites W2109587698 @default.
- W2159999251 cites W2114516136 @default.
- W2159999251 cites W2129157803 @default.
- W2159999251 cites W2156761524 @default.
- W2159999251 cites W2158068988 @default.
- W2159999251 cites W2158534713 @default.
- W2159999251 cites W2172465365 @default.
- W2159999251 cites W4248107770 @default.
- W2159999251 cites W1671726061 @default.
- W2159999251 doi "https://doi.org/10.5012/bkcs.2009.30.6.1313" @default.
- W2159999251 hasPublicationYear "2009" @default.
- W2159999251 type Work @default.
- W2159999251 sameAs 2159999251 @default.
- W2159999251 citedByCount "3" @default.
- W2159999251 countsByYear W21599992512016 @default.
- W2159999251 countsByYear W21599992512022 @default.
- W2159999251 countsByYear W21599992512023 @default.
- W2159999251 crossrefType "journal-article" @default.
- W2159999251 hasAuthorship W2159999251A5005934892 @default.
- W2159999251 hasAuthorship W2159999251A5013462262 @default.
- W2159999251 hasAuthorship W2159999251A5017742425 @default.
- W2159999251 hasAuthorship W2159999251A5024729840 @default.
- W2159999251 hasAuthorship W2159999251A5038468542 @default.
- W2159999251 hasAuthorship W2159999251A5055386073 @default.
- W2159999251 hasBestOaLocation W21599992511 @default.
- W2159999251 hasConcept C120504264 @default.
- W2159999251 hasConcept C1491633281 @default.
- W2159999251 hasConcept C178666793 @default.
- W2159999251 hasConcept C181199279 @default.
- W2159999251 hasConcept C185592680 @default.
- W2159999251 hasConcept C21951064 @default.
- W2159999251 hasConcept C2778583388 @default.
- W2159999251 hasConcept C2780429522 @default.
- W2159999251 hasConcept C29537977 @default.
- W2159999251 hasConcept C55493867 @default.
- W2159999251 hasConcept C70721500 @default.
- W2159999251 hasConcept C86803240 @default.
- W2159999251 hasConceptScore W2159999251C120504264 @default.
- W2159999251 hasConceptScore W2159999251C1491633281 @default.
- W2159999251 hasConceptScore W2159999251C178666793 @default.
- W2159999251 hasConceptScore W2159999251C181199279 @default.
- W2159999251 hasConceptScore W2159999251C185592680 @default.
- W2159999251 hasConceptScore W2159999251C21951064 @default.
- W2159999251 hasConceptScore W2159999251C2778583388 @default.
- W2159999251 hasConceptScore W2159999251C2780429522 @default.
- W2159999251 hasConceptScore W2159999251C29537977 @default.
- W2159999251 hasConceptScore W2159999251C55493867 @default.
- W2159999251 hasConceptScore W2159999251C70721500 @default.
- W2159999251 hasConceptScore W2159999251C86803240 @default.
- W2159999251 hasIssue "6" @default.
- W2159999251 hasLocation W21599992511 @default.
- W2159999251 hasOpenAccess W2159999251 @default.
- W2159999251 hasPrimaryLocation W21599992511 @default.
- W2159999251 hasRelatedWork W2022254921 @default.
- W2159999251 hasRelatedWork W2056823054 @default.
- W2159999251 hasRelatedWork W2089473708 @default.
- W2159999251 hasRelatedWork W2156761524 @default.
- W2159999251 hasRelatedWork W2165186653 @default.
- W2159999251 hasRelatedWork W2171922219 @default.
- W2159999251 hasRelatedWork W2398868158 @default.
- W2159999251 hasRelatedWork W2418895689 @default.
- W2159999251 hasRelatedWork W27537664 @default.
- W2159999251 hasRelatedWork W3176137566 @default.
- W2159999251 hasVolume "30" @default.
- W2159999251 isParatext "false" @default.
- W2159999251 isRetracted "false" @default.
- W2159999251 magId "2159999251" @default.
- W2159999251 workType "article" @default.