FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160015346> ?p ?o ?g. }

• W2160015346 endingPage "744" @default.
• W2160015346 startingPage "735" @default.
• W2160015346 abstract "In accordance with the European Parliament and Council's directive, vitamin A and C supplements can include any of four (vitamin A) or five (vitamin C) specified compounds. This study focuses on these compounds and compares their abilities to affect the DNA and viability of cells in culture, but also their potencies to chemically oxidise the DNA nucleoside deoxyguanosine (dG). To study the vitamins' strict chemical oxidation potencies, dG was exposed to vitamin solution and the amount of the oxidation product 8'-hydroxydeoxyguanosine (8-oxodG) formed was estimated using a high-performance liquid chromatography system with electrochemical and ultraviolet detection. The vitamin's ability to cause DNA damage to promyelocytic leukaemia cells (HL-60), as detected by strand breaks, alkaline labile sites and formamido pyrimidine DNA glycosylase (FPG)-sensitive sites was, after vitamin exposure, measured using the comet assay and cytotoxicity was estimated using trypan blue staining. The results highlight that vitamin A and C compounds found in supplements do have different properties, chemically as well as in a cellular system. Among the vitamin C compounds, ascorbic acid, sodium ascorbate and calcium ascorbate stood out causing both oxidation to dG and cytotoxicity to cells. The vitamin A compounds retinol, retinyl acetate and retinal (a breakdown product found in vivo) caused oxidation of dG, while retinal was the only compound causing cytotoxicity, giving rise to an almost complete cell death. β-carotene caused, as the only vitamin compound, a small increase in FPG-sensitive sites. It is concluded that even though the compounds are found under the same name (vitamin A or C), they do have different properties linked to oxidation, cytotoxicity and DNA damage." @default.
• W2160015346 created "2016-06-24" @default.
• W2160015346 creator A5016914486 @default.
• W2160015346 creator A5028246780 @default.
• W2160015346 creator A5066897346 @default.
• W2160015346 date "2011-07-21" @default.
• W2160015346 modified "2023-10-02" @default.
• W2160015346 title "Vitamin A and C compounds permitted in supplements differ in their abilities to affect cell viability, DNA and the DNA nucleoside deoxyguanosine" @default.
• W2160015346 cites W1525444530 @default.
• W2160015346 cites W1843270395 @default.
• W2160015346 cites W1887679324 @default.
• W2160015346 cites W1964901949 @default.
• W2160015346 cites W1967026165 @default.
• W2160015346 cites W1972914529 @default.
• W2160015346 cites W1984598028 @default.
• W2160015346 cites W1988304291 @default.
• W2160015346 cites W2001541958 @default.
• W2160015346 cites W2012137858 @default.
• W2160015346 cites W2014520088 @default.
• W2160015346 cites W2019369653 @default.
• W2160015346 cites W2021294790 @default.
• W2160015346 cites W2029938621 @default.
• W2160015346 cites W2036313595 @default.
• W2160015346 cites W2044159756 @default.
• W2160015346 cites W2045492720 @default.
• W2160015346 cites W2048119515 @default.
• W2160015346 cites W2063625486 @default.
• W2160015346 cites W2068353537 @default.
• W2160015346 cites W2070661653 @default.
• W2160015346 cites W2078864612 @default.
• W2160015346 cites W2088442630 @default.
• W2160015346 cites W2094026377 @default.
• W2160015346 cites W2098689751 @default.
• W2160015346 cites W2115686884 @default.
• W2160015346 cites W2125586202 @default.
• W2160015346 cites W2127890450 @default.
• W2160015346 cites W2141083396 @default.
• W2160015346 cites W2159209241 @default.
• W2160015346 cites W2161007782 @default.
• W2160015346 cites W2161427454 @default.
• W2160015346 cites W2165104560 @default.
• W2160015346 cites W2315403385 @default.
• W2160015346 cites W2317242858 @default.
• W2160015346 doi "https://doi.org/10.1093/mutage/ger041" @default.
• W2160015346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778356" @default.
• W2160015346 hasPublicationYear "2011" @default.
• W2160015346 type Work @default.
• W2160015346 sameAs 2160015346 @default.
• W2160015346 citedByCount "14" @default.
• W2160015346 countsByYear W21600153462012 @default.
• W2160015346 countsByYear W21600153462013 @default.
• W2160015346 countsByYear W21600153462015 @default.
• W2160015346 countsByYear W21600153462016 @default.
• W2160015346 countsByYear W21600153462017 @default.
• W2160015346 countsByYear W21600153462020 @default.
• W2160015346 countsByYear W21600153462021 @default.
• W2160015346 crossrefType "journal-article" @default.
• W2160015346 hasAuthorship W2160015346A5016914486 @default.
• W2160015346 hasAuthorship W2160015346A5028246780 @default.
• W2160015346 hasAuthorship W2160015346A5066897346 @default.
• W2160015346 hasBestOaLocation W21600153461 @default.
• W2160015346 hasConcept C143425029 @default.
• W2160015346 hasConcept C1491633281 @default.
• W2160015346 hasConcept C185592680 @default.
• W2160015346 hasConcept C2776543447 @default.
• W2160015346 hasConcept C2776940978 @default.
• W2160015346 hasConcept C2780441211 @default.
• W2160015346 hasConcept C2986274086 @default.
• W2160015346 hasConcept C31903555 @default.
• W2160015346 hasConcept C53227056 @default.
• W2160015346 hasConcept C552990157 @default.
• W2160015346 hasConcept C55493867 @default.
• W2160015346 hasConceptScore W2160015346C143425029 @default.
• W2160015346 hasConceptScore W2160015346C1491633281 @default.
• W2160015346 hasConceptScore W2160015346C185592680 @default.
• W2160015346 hasConceptScore W2160015346C2776543447 @default.
• W2160015346 hasConceptScore W2160015346C2776940978 @default.
• W2160015346 hasConceptScore W2160015346C2780441211 @default.
• W2160015346 hasConceptScore W2160015346C2986274086 @default.
• W2160015346 hasConceptScore W2160015346C31903555 @default.
• W2160015346 hasConceptScore W2160015346C53227056 @default.
• W2160015346 hasConceptScore W2160015346C552990157 @default.
• W2160015346 hasConceptScore W2160015346C55493867 @default.
• W2160015346 hasIssue "6" @default.
• W2160015346 hasLocation W21600153461 @default.
• W2160015346 hasLocation W21600153462 @default.
• W2160015346 hasOpenAccess W2160015346 @default.
• W2160015346 hasPrimaryLocation W21600153461 @default.
• W2160015346 hasRelatedWork W2061078869 @default.
• W2160015346 hasRelatedWork W2570025094 @default.
• W2160015346 hasRelatedWork W2717843124 @default.
• W2160015346 hasRelatedWork W2769826361 @default.
• W2160015346 hasRelatedWork W2950666140 @default.
• W2160015346 hasRelatedWork W2950968125 @default.
• W2160015346 hasRelatedWork W2951287109 @default.
• W2160015346 hasRelatedWork W2951760521 @default.
• W2160015346 hasRelatedWork W3756749 @default.
• W2160015346 hasRelatedWork W4290151739 @default.

• next