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• W2160034730 abstract "ABSTRACT Viral factors as well as host ones play major roles in the disease progression of human immunodeficiency virus type 1 (HIV-1) infection. We have examined cytotoxic T-lymphocyte activity and HIV-1 DNA PCR results of 312 high-risk seronegative drug users in northern Thailand and identified four seronegative cases positive for both assays. Furthermore, we have identified a synonymous mutation in nucleotide position 75 of the gag p17 gene (A426G) of HIV-1 that belongs to the CRF01_AE virus circulating in Thailand. The replication-competent HIV-1 clone containing the A426G mutation demonstrated a dramatic reduction of virion production and perturbation of viral morphogenesis without affecting viral protein synthesis in cells." @default.
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• W2160034730 date "2007-02-01" @default.
• W2160034730 modified "2023-09-26" @default.
• W2160034730 title "A Single-Nucleotide Synonymous Mutation in the gag Gene Controlling Human Immunodeficiency Virus Type 1 Virion Production" @default.
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• W2160034730 doi "https://doi.org/10.1128/jvi.01596-06" @default.
• W2160034730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1797536" @default.
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