FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160057583> ?p ?o ?g. }

• W2160057583 abstract "A number of ion transport defects have been described in human red blood cells (RBC) from patients with essential hypertension. Insulin resistance is also frequently present in hypertensive patients and insulin levels in vitro correlate with red blood cell Na+/H+ exchange (NHE) activity. We studied the kinetics of insulin-stimulated NHE activity in freshly isolated RBC from 14 patients with essential hypertension and 8 normotensive subjects. We measured an estimate of maximal activity (Vmax) for NHE activity as net Na+ influx driven by an outward H+ gradient in acid-loaded and Na+-depleted erythrocytes. NHE activity was significantly greater in hypertensives than in normotensives (22.0 vs 14.5 mmol/L cell x h, respectively; P<0.01). When RBC were pre-incubated with a physiologic dose of insulin (100 microU/mL), NHE activity increased significantly in both groups but the increase was greater in normotensives than in hypertensives (9.6 vs 8.5 mmol/L cell x h, respectively; P < 0.05). Phosphatidylinositol-3 kinase (PI-3 kinase) inhibitors, wortmannin and LY294,002, had no effect on basal NHE activity but similarly and significantly inhibited insulin-stimulated NHE activity in both normal and hypertensive subjects. Insulin increased the Km for extracellular Na+ in normotensive subjects but not in hypertensive patients. In addition, the dose response curve for insulin and NHE activity showed that the curve for hypertensive patients was shifted rightward in relation to the normotensive subjects. These data suggest that insulin stimulates RBC NHE activity in vitro and this activation is mediated via a pathway that includes activation of PI-3 kinase. Hypertensive patients have elevated basal NHE activity but a blunted response to insulin suggesting that RBC may be a model to study insulin resistance in essential hypertensive patients." @default.
• W2160057583 created "2016-06-24" @default.
• W2160057583 creator A5006676605 @default.
• W2160057583 creator A5054212880 @default.
• W2160057583 creator A5080357111 @default.
• W2160057583 date "2002-01-01" @default.
• W2160057583 modified "2023-09-27" @default.
• W2160057583 title "RED BLOOD CELL Na+/H+EXCHANGE ACTIVITY IS INSULIN RESISTANT IN HYPERTENSIVE PATIENTS" @default.
• W2160057583 cites W1487174454 @default.
• W2160057583 cites W1518719712 @default.
• W2160057583 cites W1554264637 @default.
• W2160057583 cites W1966249072 @default.
• W2160057583 cites W1983242348 @default.
• W2160057583 cites W1999241019 @default.
• W2160057583 cites W2061567663 @default.
• W2160057583 cites W2076186944 @default.
• W2160057583 cites W2088924345 @default.
• W2160057583 cites W2091319839 @default.
• W2160057583 cites W2092740788 @default.
• W2160057583 cites W2111661290 @default.
• W2160057583 cites W2113850105 @default.
• W2160057583 cites W2163129250 @default.
• W2160057583 cites W2164340474 @default.
• W2160057583 cites W2205832248 @default.
• W2160057583 cites W4247596208 @default.
• W2160057583 doi "https://doi.org/10.1081/ceh-120004231" @default.
• W2160057583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12069358" @default.
• W2160057583 hasPublicationYear "2002" @default.
• W2160057583 type Work @default.
• W2160057583 sameAs 2160057583 @default.
• W2160057583 citedByCount "5" @default.
• W2160057583 countsByYear W21600575832018 @default.
• W2160057583 crossrefType "journal-article" @default.
• W2160057583 hasAuthorship W2160057583A5006676605 @default.
• W2160057583 hasAuthorship W2160057583A5054212880 @default.
• W2160057583 hasAuthorship W2160057583A5080357111 @default.
• W2160057583 hasConcept C126322002 @default.
• W2160057583 hasConcept C134018914 @default.
• W2160057583 hasConcept C184235292 @default.
• W2160057583 hasConcept C185592680 @default.
• W2160057583 hasConcept C2776557347 @default.
• W2160057583 hasConcept C2777097880 @default.
• W2160057583 hasConcept C2777391703 @default.
• W2160057583 hasConcept C2778024521 @default.
• W2160057583 hasConcept C2778308172 @default.
• W2160057583 hasConcept C2779306644 @default.
• W2160057583 hasConcept C2780610907 @default.
• W2160057583 hasConcept C28406088 @default.
• W2160057583 hasConcept C55493867 @default.
• W2160057583 hasConcept C71924100 @default.
• W2160057583 hasConcept C84393581 @default.
• W2160057583 hasConceptScore W2160057583C126322002 @default.
• W2160057583 hasConceptScore W2160057583C134018914 @default.
• W2160057583 hasConceptScore W2160057583C184235292 @default.
• W2160057583 hasConceptScore W2160057583C185592680 @default.
• W2160057583 hasConceptScore W2160057583C2776557347 @default.
• W2160057583 hasConceptScore W2160057583C2777097880 @default.
• W2160057583 hasConceptScore W2160057583C2777391703 @default.
• W2160057583 hasConceptScore W2160057583C2778024521 @default.
• W2160057583 hasConceptScore W2160057583C2778308172 @default.
• W2160057583 hasConceptScore W2160057583C2779306644 @default.
• W2160057583 hasConceptScore W2160057583C2780610907 @default.
• W2160057583 hasConceptScore W2160057583C28406088 @default.
• W2160057583 hasConceptScore W2160057583C55493867 @default.
• W2160057583 hasConceptScore W2160057583C71924100 @default.
• W2160057583 hasConceptScore W2160057583C84393581 @default.
• W2160057583 hasLocation W21600575831 @default.
• W2160057583 hasLocation W21600575832 @default.
• W2160057583 hasOpenAccess W2160057583 @default.
• W2160057583 hasPrimaryLocation W21600575831 @default.
• W2160057583 hasRelatedWork W1966187582 @default.
• W2160057583 hasRelatedWork W1966324594 @default.
• W2160057583 hasRelatedWork W1975704800 @default.
• W2160057583 hasRelatedWork W1989912317 @default.
• W2160057583 hasRelatedWork W2001313096 @default.
• W2160057583 hasRelatedWork W2003289270 @default.
• W2160057583 hasRelatedWork W2019129193 @default.
• W2160057583 hasRelatedWork W2023081656 @default.
• W2160057583 hasRelatedWork W2032335205 @default.
• W2160057583 hasRelatedWork W2037684570 @default.
• W2160057583 hasRelatedWork W2040283223 @default.
• W2160057583 hasRelatedWork W2042305440 @default.
• W2160057583 hasRelatedWork W2047266777 @default.
• W2160057583 hasRelatedWork W2066831270 @default.
• W2160057583 hasRelatedWork W2069056604 @default.
• W2160057583 hasRelatedWork W2099750404 @default.
• W2160057583 hasRelatedWork W2205538242 @default.
• W2160057583 hasRelatedWork W2317664612 @default.
• W2160057583 hasRelatedWork W2324744387 @default.
• W2160057583 hasRelatedWork W2397223071 @default.
• W2160057583 isParatext "false" @default.
• W2160057583 isRetracted "false" @default.
• W2160057583 magId "2160057583" @default.
• W2160057583 workType "article" @default.