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• W2160059242 abstract "The unfolded protein response (UPR) is induced at symptom onset and disease end stage in rodent models of familial amyotrophic lateral sclerosis (ALS) that express superoxide dismutase (SOD1) mutations. However, ninety percent of human ALS is sporadic and mutations in SOD1 account for only 2% of total ALS. Here we show that a full UPR, including induction of stress sensor kinases, chaperones and apoptotic mediators, is also present in spinal cords of human patients with sporadic disease. Furthermore, the UPR chaperone protein disulphide isomerase (PDI) was present in CSF and was aggregated and widely distributed throughout the motor neurons of these patients. We also show up-regulation of UPR prior to the onset of symptoms in SOD1 rodents, implying an active role in disease. This study offers new insights into pathogenesis, placing ER stress onto a generic pathophysiology for ALS." @default.
• W2160059242 created "2016-06-24" @default.
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• W2160059242 date "2008-06-01" @default.
• W2160059242 modified "2023-10-12" @default.
• W2160059242 title "RETRACTED: Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis" @default.
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• W2160059242 doi "https://doi.org/10.1016/j.nbd.2008.02.009" @default.
• W2160059242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18440237" @default.
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